Slow-releasing tablets of oral medicine and preparation thereof
A technology for sustained-release tablets and oral medicines, which is applied in the field of oral drug sustained-release tablets and its preparation, which can solve problems such as inability to achieve a good sustained-release effect, achieve enhanced blocking effects, ensure sustained-release effects, and reduce The effect of release area
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Embodiment 1
[0037] First, put the raw materials and auxiliary materials at 60°C and dry them for 4 hours, pass through a 80-mesh sieve, and set aside; then, prepare a drug-free blank layer: take 200 g of glyceryl behenate, polyvinylpyrrolidone (PVP) K30 15g was mixed uniformly by the method of increasing in equal amounts, passed through a 60-mesh sieve, and dry-granulated; the second drug-containing slow-release layer of the preparation layer: metformin hydrochloride 500g, glyceryl behenate 150g, polyvinylpyrrolidone (PVP) K30 20g were increased in equal amounts Mix evenly by 60-mesh sieve, dry granulate, and weigh; Tablet: layer 1 and layer 2 are mixed with 1% magnesium stearate respectively, and the particles of layer 1 and layer 2 are separated into two hoppers in a double-layer Compressed into 1000 tablets on a tablet press, each containing 500 mg of metformin hydrochloride. The blood concentration-time curve after taking the medicine is shown in Figure 2.
Embodiment 2
[0039] First, put the raw materials and auxiliary materials at 60°C for 4 hours, pass through an 80-mesh sieve for later use; then, prepare a blank layer without drugs: take 275g of high-viscosity hydroxypropyl methylcellulose, polyvinylpyrrolidone (PVP) K30 15g was uniformly mixed according to equal increment method, passed through a 60-mesh sieve, dry-granulated, and weighed; preparation layer 2 slow-release layer: get metformin hydrochloride 500g, hydroxypropyl methylcellulose 150g, polyvinylpyrrolidone ( PVP) K30 15g is mixed evenly by the method of equal increment, passed through a 60-mesh sieve, dry granulated, and weighed; tableting: layer 1 and layer 2 are mixed with 1% micropowder silica gel respectively, and the particles of layer 1 and layer 2 are separated Two hoppers are pressed into 1000 tablets on a double-layer tablet press, and each tablet contains 500 mg of metformin hydrochloride. The blood drug concentration-time curve after taking the medicine is similar t...
Embodiment 3
[0041] First, put the raw materials and auxiliary materials at 60°C for 4 hours, pass through an 80-mesh sieve for later use; then, prepare a blank layer without drugs: take 300 g of ethyl cellulose, 15 g of polyvinylpyrrolidone (PVP) K30 and press Mix evenly by the equal-volume incremental method, pass through a 60-mesh sieve, use water as a binder, wet granulate, and weigh; prepare the second sustained-release layer: take 500g of metformin hydrochloride, 200g of ethyl cellulose, and polyvinylpyrrolidone (PVP) K30 10g was mixed evenly by the method of equal increment, passed through a 60-mesh sieve, wet granulated, and weighed; tableting: layer 1 and layer 2 were mixed with 1% magnesium stearate respectively, and the granules of layer 1 and layer 2 were separated into two A hopper is compressed into 1000 tablets on a double-layer tablet press, and each tablet contains 500 mg of metformin hydrochloride. The blood drug concentration-time curve after taking medicine is similar t...
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