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Method for identifying individual at risk for irreversible neurodamages, comprising steps of determining quantatively concentration of pepsinogen I(PGI) and vitamin B12

A technology for nerve damage, vitamins, applied in the field of combined diagnosis

Inactive Publication Date: 2002-06-12
BIOHIT OYJ
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Of particular value is the ability of the treatment to identify individuals who have not currently developed B12 vitamin deficiency but who are at considerable risk of developing the disease in the future unless steps are taken to prevent progression of the deficiency

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] 1. Detection of pepsinogen I (PGI)

[0019] Detection of PGI in serum samples can be performed as described in WO96 / 15456, which publication is incorporated herein by reference.

[0020] The above-mentioned method preferably comprises the step of detecting pepsinogen I using a poly or monoclonal antibody against pepsinogen I in an immunological method. Preferably the reaction is carried out on a suitable support, such as a plastic, glass or cellulose support, eg a microtiter plate. Immunological methods can be performed in a known manner, such as using absorbance, luminescence or fluorescence techniques to detect the concentration of pepsinogen I in the above-mentioned samples.

[0021] In this case, the method-specific threshold for serum PGI is chosen according to the specificity and sensitivity of the assay used to detect the analyte concentration, and is well known to those skilled in the art, see, for example, William J Marshall, Clinical Chemistry, Third Edition...

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Abstract

The present invention is aimed at a method and a kit for identifying an individual at risk for irreversible neurological damage and pernicious anaemia, the method comprising the steps of determining quantitatively the pepsinogen I (PGI) analyte concentrations in a serum sample from said individual, selecting a method specific cut-off value for the said analyte, comparing the analyte concentration so determined to the method-specific cut-off value for the analyte, and determining the B12-vitamin concentration or the concentration of an analyte correlating thereto, in a serum sample from the individual.

Description

field of invention [0001] The present invention relates to a combined diagnostic method for identifying susceptible individuals to irreversible neurological damage, including dementia. [0002] The method of the present invention is based on the combination of two tests performed on blood or serum samples, in particular to identify patients predisposed to B12 deficiency and likely to suffer from this deficiency, such as irreversible neurological damage, including dementia and pernicious anemia. Background of the invention [0003] Many different stomach diseases or conditions, such as chronic atrophic gastritis, pernicious anemia, ventricular ulcers, gastric polyps, and Menetrier's disease (giant hypertrophic gastritis) can lead to stomach cancer. Clearly recognizable changes of the mucosa are dysplasia and adenocarcinoma. It has been proven that the risk of almost all diseases is mediated by chronic atrophic gastritis. [0004] Chronic gastritis ref...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/12A61P25/00G01N33/573G01N33/68G01N33/82
CPCG01N2333/96472G01N2333/82G01N33/573G01N33/6896A61P25/00
Inventor 彭蒂·西波南马蒂·哈科南奥斯莫·斯沃瓦尼米埃里克·福斯布洛姆
Owner BIOHIT OYJ