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Method and apparatus for spectrometric aralysis of turbid, pharamceutical samples

A sample, drug technology, applied in the field of analysis of opaque drug samples

Inactive Publication Date: 2002-10-23
ASTRAZENECA AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These prior art methods are not suitable for performing quantitative analyzes of opaque samples of pharmaceuticals, such as tablets or capsules, in order to determine e.g. content and structural parameters

Method used

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  • Method and apparatus for spectrometric aralysis of turbid, pharamceutical samples
  • Method and apparatus for spectrometric aralysis of turbid, pharamceutical samples
  • Method and apparatus for spectrometric aralysis of turbid, pharamceutical samples

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Embodiment Construction

[0036] Description of preferred embodiments

[0037] Referring now to FIG. 1a, an apparatus according to a first embodiment for performing time-resolved analysis according to the invention comprises a titanium (Ti):sapphire laser 10 pumped by an argon ion laser 12 . The resulting laser beam 14 is amplified by an NdYAG amplifier stage 16 into an amplified laser beam 18 . To generate a laser beam 20 of "white" light, the laser beam 18 passes through a transparent container 22 filled with water via a mirror M1 and a first lens system L1.

[0038] A sample to be analyzed is schematically illustrated at reference numeral 24 and includes a front surface 26 and a back surface 28 . Sample 24 is temporarily held in a sample positioning device (not shown). Excitation laser beam 20 is focused on front surface 26 of sample 24 by lens system L2 / L3 and mirrors M2-M4. On the opposite side of the sample 24, the transmitted laser beam 30 is collected from the rear by a le...

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Abstract

The present invention relates to methods and devices for the quantitative analysis of opaque pharmaceutical samples, such as tablets, capsules or similar samples constituting pharmaceutical doses. An opaque sample of drug (24) is irradiated with an excitation beam (20) of radiation, such as near infrared radiation. The intensity (30) of radiation emitted by the sample (24) is detected as a function of both the wavelength of the emitted radiation and the travel time of photons through the sample (24). Optionally, the intensity (30) of the radiation emitted by the sample (24) is also detected in a spatially resolved manner.

Description

field of invention [0001] The present invention relates to a method for the analysis of opaque pharmaceutical samples, such as tablets, capsules - in particular tablets or capsules of the Multi-Particle Form (MUPS) - or similar samples constituting a pharmaceutical dose. The invention also relates to a device for carrying out such a method. [0002] The present invention may optionally be combined with the invention and spectrometry method and apparatus as disclosed in applicant's co-pending International Patent Application WO 099 / 49312, which was filed prior to the present application but not prior to The priority date of this application was published. In particular, the invention can be combined with the technique disclosed there for illuminating two opposing surfaces of a sample to be analyzed in order to obtain a signal representative of the three-dimensional distribution of at least one component in the sample. The content of this International Patent Application is he...

Claims

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Application Information

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IPC IPC(8): G01N21/35G01J3/44G01N21/33G01N21/359G01N21/39G01N21/47G01N21/51G01N21/53
CPCG01J3/4412G01N21/33G01N21/35G01N21/359G01N21/47G01N21/51G01N21/532G01N21/534G01N2021/399G01N21/3563G06V20/66G01N21/25
Inventor S·福莱斯塔M·约瑟夫松A·斯帕伦J·约翰松
Owner ASTRAZENECA AB
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