Androgen receptor suppressors in treatment of hirsutism,acne and androgenetic alopecia

A technology of compounds and mixtures, applied in the field of androgen receptor inhibitors in the treatment and diagnosis of prostate cancer, alopecia and other androgen excess syndromes, can solve the problem of harmless long-term systemic treatment
CN1416416AInactive Publication Date: 2003-05-07BIOPHYSICA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BIOPHYSICA
Publication Date
2003-05-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention providing compound (2-hydroxy-2-methyl-N-(4-X-3-(trifluoromethyl)phenyl)-3-(2,2,2-perfluo roacylamino)propionamide) applied topically, specifically inhibits and / or eliminates cutaneous androgen receptors and thus finds cosmetic use in skin afflictions associated with excess androgens such as hair effluvium, hirsutism, acne and androgenic alopecia.
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Description

Technical field

[0001] The field of the invention is compounds and their use in the treatment of prostate cancer and hyperandrogen syndromes including alopecia, hirsutism and acne vulgaris. Background technique

[0002] The existence of a variety of pathological syndromes depends on male hormones. Therefore, the growth of prostate cancer is driven by androgens at an early stage, and may, at least temporarily, stop due to androgen loss. Androgenetic alopecia is caused by an unexplained reason that androgens switch from promoting the growth of hair follicles to hair loss. In skin androgen-mediated diseases, such as hair loss, acne vulgaris and hirsutism, excessive androgen in the skin is found to be the main pathogenic factor.

[0003] People still do not fully understand the pathophysiology of male and female hair loss and the treatment is unsatisfactory. People recognize that scalp blood flow, lack of nutrition and vitamins related to hair, and inflammatory lesions caused by micr...

Claims

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