Synthesis process of primisulfuron-methy and other fluoric hebicide

[0012] Embodiment: For the key intermediate 2-amino of synthetic flurimsulfuron methyl, the reaction of 4,6 bis (difluoromethoxy) pyrimidines:

[0013] The specific operation is as follows, 1.27g (0.01mol) of 2-amino, 4,6-dihydroxypyrimidine, 0.007mol of Cu + catalyst while adding 30ml of CH 3 CN was used as a solvent, put it into the reflux tube and a thermometer, filled with nitrogen gas protection, added dropwise 4.5g (0.025mol) fluorosulfone difluoroacetic acid, raised the temperature to 50°C, and reacted for 3 hours. After the reaction was completed, filter, and evaporate the filtrate to its solvent. After cooling, a solid was precipitated, and the resulting solid was washed with 5% NaOH solution to obtain a crude product, which was separated by column chromatography (developing solvent: V (petroleum ether): V (ethyl acetate) = 5: 1) to obtain a white needle. 0.4 g of solid crystals, yield 18%. The obtained crystals were examined: m.p, 68~69°C; H-NMR, δ: (CDCl 3 /TMS), 5.10 (S, 2H, NH 2 ); 5.80 (S, H, CH), 7.38 (t, 2H, CHF 2 );1 9 F-NMR, δ: (CDCl 3 )5.85(t, 2F, CF 2 H), MS, M/z: 227 (M + ), 177 (M + -CF 2 ), 161 (M + -OCF 2 ), 127 (M + -2CF 2 ), 68 (HOCF 2 H), 51 (CF 2 h).

[0014] Elemental analysis: (theory/experiment): C: 31.73/31.65, H: 2.22/2.14, N: 18.5/18.58.

[0015] After analysis, the resulting product is 2-amino, 4,6-bis(difluoromethoxy)pyrimidine, then react it with o-methoxyformylbenzenesulfonyl isocyanate, and use acetonitrile as solvent to obtain the final Product Fluorosulfuron-methyl herbicide.