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Cresol powder with dissolution increased and its preparing method-analgesic, antipyretic and anti-inflammatory agent

A technology of mefenamic acid and dispersible tablets, which is used in the preparation of anti-inflammatory drugs, non-steroidal analgesia, and antipyretic fields, can solve the problems of low dissolution rate, poor curative effect of ordinary tablets and capsules, mefenamic acid Clinical application limitations and other issues

Inactive Publication Date: 2003-10-01
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Mefenamic acid is insoluble in water, the dissolution rate of ordinary tablets and capsules is low, and the curative effect is poor, which greatly limits the clinical application of mefenamic acid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 2

[0058] Mefenamic Acid 250g

[0059] Lactose 30g

[0060] Low-substituted hydroxypropyl cellulose 20g

[0061] Micronized silica gel 20g

[0062] Microcrystalline Cellulose 80g

[0063] Cross-linked polyvinylpyrrolidone 20g

[0064] Sodium carboxymethyl starch 30g

[0065] Tween-80 5g

[0066] Poloxamer 5g

[0067] Appropriate amount of flavoring agent

[0068] Magnesium Stearate 1.5g

[0069] 60% ethanol appropriate amount

example 3

[0071] Mefenamic Acid 250g

[0072] Lactose 80g

[0073] Micronized silica gel 30g

[0074] Microcrystalline Cellulose 100g

[0075] Cross-linked polyvinylpyrrolidone 20g

[0076] Croscarmellose Sodium 20g

[0077] Tween-80 4g

[0078] Poloxamer 5g

[0079] Polyvinylpyrrolidone K30 1g

[0080] 50% ethanol appropriate amount

[0081] Appropriate amount of flavoring agent

[0082] Magnesium Stearate 2g

example 4

[0084] Mefenamic Acid 250g

[0085] Lactose 100g

[0086] Micronized silica gel 30g

[0087] Microcrystalline Cellulose 60g

[0088] Cross-linked polyvinylpyrrolidone 35g

[0089] Croscarmellose Sodium 15g

[0090] Tween-80 5g

[0091] Poloxamer 5g

[0092] 30% ethanol appropriate amount

[0093] Appropriate amount of flavoring agent

[0094] Magnesium Stearate 2g

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PUM

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Abstract

A mefenamic acid dispersing tablet with high solubility is prepared from mefenamic acid, filler, adhesive, disintegrant and / or disintegration assistant, adsorbent, flowing, assistant, suspending agent or resistance, flavouring, surfactant, wetting agent and lubricant.

Description

technical field [0001] The invention relates to a preparation of non-steroidal analgesic, antipyretic and anti-inflammatory drugs, in particular to a formula of mefenamic acid dispersible tablets capable of improving dissolution rate and a preparation method thereof. technical background [0002] Mefenamic acid is a non-steroidal analgesic, antipyretic, and anti-inflammatory drug. It has analgesic, antipyretic and anti-inflammatory effects, and its anti-inflammatory effect is strong. [0003] Acute toxicity test results show that mefenamic acid rats and mice orally administered LD 50 780mg / kg and 630mg / kg respectively. [0004] The results of pharmacokinetic studies show that the plasma concentration of mefenamic acid reaches a peak within 2-4 hours after oral administration of 1 g, and the peak value is 10 μg / ml. Oral 4 times a day, the steady state can be reached in 2 days (plasma concentration is 20μg / ml). Biotransformed by the liver, T 1 / 2 for 2 hours. 67% is excre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/44A61P29/00
Inventor 刘智许军彭红钱进刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG