Recombination low-dosage human alpha-2b(IFN-alpha-2b) interferon lozenge and preparing method thereof

An interferon, low-dose technology, applied in the field of medical and bioengineering, can solve the problems of small number of subtypes and unsatisfactory disease curative effect, and achieve the effect of obvious curative effect.

Inactive Publication Date: 2004-02-04
山东泉港药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Australia's Namalwa cell interferon buccal tablet is a kind of lymphoblastoid interferon. This kind of interferon is made of lymphoma, which is a normal tissue of a non-healthy human body, and the number of subtypes is small, so the curative effect on the disease is not ideal , therefore, my country has not approved the import

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A low-dose recombinant human α-2b (IFN-α-2b) interferon buccal tablet of the present invention, its formula is:

[0032] Low dose recombinant human α-2b (IFN-α-2b) interferon 100IU

[0033] Trehalose Powder 6%

[0034] Maltose powder 5%

[0035] Powdered sugar 55%

[0036] Starch 31%

[0037] Gelatin powder 2%

[0038] Magnesium Stearate 1%

Embodiment 2

[0040] A low-dose recombinant human α-2b (IFN-α-2b) interferon buccal tablet of the present invention, its formula is:

[0041] Low dose recombinant human α-2b (IFN-α-2b) interferon 300IU

[0042] Trehalose Powder 8%

[0043] Maltose Powder 6%

[0044] Powdered sugar 48%

[0045]Starch 35%

[0046] Gelatin powder 2%

[0047] Magnesium Stearate 1%

Embodiment 3

[0049] A low-dose recombinant human α-2b (IFN-α-2b) interferon buccal tablet of the present invention, its formula is:

[0050] Low dose recombinant human α-2b (IFN-α-2b) interferon 1000IU

[0051] Trehalose Powder 8%

[0052] Maltose Powder 8%

[0053] Powdered sugar 46%

[0054] Starch 35%

[0055] Gelatin powder 2%

[0056] Magnesium Stearate 1%

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PUM

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Abstract

A buccal lozenge for treating SARS, hepatitis B, hepatitis C and tumor is prepared from low-dosage recombinant human alpha-2b(IFN-alpha-2b) interferon and medical auxiliaries including mycose, maltose, sugar powder, staroh, gelatin and magnesium stearate. Its advantages are high curative effect, low poison, and low cost.

Description

Technical field [0001] The invention relates to the technical field of medical bioengineering, in particular to preparation of buccal tablets by using low-dose recombinant human alpha-2b (IFN-alpha-2b) interferon and a preparation method thereof. Background technique [0002] As a cytokine, interferon has a wide range of biological functions, such as anti-virus, anti-tumor, immune regulation, regulation of cell proliferation and differentiation, etc., and has been approved for clinical treatment in more than 40 countries. However, intramuscular injection or intravenous infusion is mostly used for its drug administration, and the injection dose is relatively large, generally 1 million to 6 million IU. The dosage of interferon buccal tablets is relatively low (100-10000IU). Australia's Namalwa cell interferon buccal tablet is a kind of lymphoblastoid interferon. This kind of interferon is made of lymphoma, which is a normal tissue of a non-healthy human body, and the number o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K38/21A61P31/12A61P35/00A61P37/02
Inventor 陈文芳刘红军宋磊邹立家
Owner 山东泉港药业有限公司
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