Hyaluronic acid gel with iron ion and medicine used for preventing adhesion after operation

A technology of hyaluronic acid and iron ions, which is applied in the direction of surgical drugs, drug combinations, drug delivery, etc., can solve the problems that the prevention of adhesion can not achieve the desired effect, and the retention time is short, so as to achieve long retention time and solve anti-adhesion , good biocompatibility

Inactive Publication Date: 2004-02-11
YINYI BIOLOGICAL MATERICAL RES & DEV DALIAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the short retention time of natural hyaluronic acid at th...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The hyaluronic acid gel with medicine and iron ions for postoperative anti-adhesion, the preparation method is as follows:

[0036] (1) adding hyaluronic acid into deionized water to prepare a hyaluronic acid solution with a mass percentage of 1%, and fully stir until dissolved;

[0037] (2) FeCl 3 Add 1M HCl to configure FeCl with a mass volume concentration of 1.5% 3 solution;

[0038] (3) Add 1M HCl dropwise to the hyaluronic acid solution while stirring to fully mix the two until the pH value reaches 4.75;

[0039] (4) FeCl with a volume ratio of 3:10 to the above solution 3 The solution was added dropwise to the above solution, fully stirred for 10-20min;

[0040] (5) Add 1M NaOH dropwise to the above solution until the solution becomes a gel and the pH value is 7;

[0041] (6) The above-mentioned gel is freeze-dried and pressed into powder;

[0042] (7) Put the above-mentioned powder into a disinfection cabinet and disinfect it with ozone for 2 times;

[00...

Embodiment 2

[0046] The hyaluronic acid gel with medicine and iron ions for postoperative anti-adhesion, the preparation method is as follows:

[0047] (1) adding hyaluronic acid into deionized water to prepare a hyaluronic acid solution with a mass percentage of 1%, and fully stir until dissolved;

[0048] (2) FeCl 3 Add 1M HCl to configure FeCl with a mass volume concentration of 1.5% 3 solution;

[0049] (3) Add 1M HCl dropwise to the hyaluronic acid solution while stirring to fully mix the two until the pH value reaches 4.75;

[0050] (4) FeCl with a volume ratio of 3:10 to the above solution 3 The solution was added dropwise to the above solution, fully stirred for 10~20min;

[0051] (5) Add 1M NaOH dropwise to the above solution until the solution becomes a gel and the pH value is 7;

[0052] (6) The above-mentioned gel is freeze-dried and pressed into powder;

[0053] (7) UV irradiation of the above-mentioned powder;

[0054] (8) Mix the above powder and Tranister drug powder...

Embodiment 3

[0056] The hyaluronic acid gel with medicine and iron ions for postoperative anti-adhesion, the preparation method is as follows:

[0057] (1) adding hyaluronic acid into deionized water to prepare a hyaluronic acid solution with a mass percentage of 1%, and fully stir until dissolved;

[0058] (2) FeCl 3 Add 1M HCl to configure FeCl with a mass volume concentration of 1.5% 3 solution;

[0059] (3) Add 1M HCl dropwise to the hyaluronic acid solution while stirring to fully mix the two until the pH value reaches 4.75;

[0060] (4) FeCl with a volume ratio of 3:10 to the above solution 3 The solution was added dropwise to the above solution, fully stirred for 10~20min;

[0061] (5) Add 1M NaOH dropwise to the above solution until the solution becomes a gel and the pH value is 7;

[0062] (6) The above-mentioned gel is freeze-dried and pressed into powder;

[0063] (7) Put the above powder into Co 60 irradiation disinfection;

[0064] (8) Mix the above powder and Traniste...

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PUM

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Abstract

The present invention relates to a novel adhesion preventing agent with wide application in preventing post-operation adhesion. The present invention features that under acid condition, hyaluronic acid and ferric chloride are mixed for full crosslinking to form iron crosslinked hyaluronic acid derivative with increased molecular weight and prolonged degradation period, and organic high molecular matter capable of suppressing collagen synthesis is then added to further strengthen the adhesion preventing effect. The adhesion preventing biological material of the present invention has good biocompatibility and long retention period inside body, and can prevent post-operation adhesion effectively before degrading automatically into harmless matter.

Description

[0001] Field [0002] The invention belongs to a novel anti-adhesion agent, in particular hyaluronic acid gel with medicine and iron ions for anti-adhesion after operation, and has a very wide application in the field of preventing tissue adhesion after operation. Background technique [0003] 1. The cause of anti-blocking agent [0004] The development of anti-adhesion agents originated from the medical profession's concern about post-surgical adhesions. Adhesions increase the difficulty of reoperation and the potential risk of further complications. Therefore, in-depth exploration of the causes of adhesion formation to prevent and reduce postoperative adhesions has become a key research direction in the field of surgery today. At present, there are two commonly used methods for reducing adhesions: 1) direct perfusion of various substances to reduce or inhibit the formation of fibrous connective tissue (Wiseman D. Polymers for the prevention of surgical adhesions. In: Domb ...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/728A61P41/00
Inventor 崔福斋田维明张存理俞兴董保彦
Owner YINYI BIOLOGICAL MATERICAL RES & DEV DALIAN
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