Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Hyaluronic acid gel with iron ion and medicine used for preventing adhesion after operation

A technology of hyaluronic acid and iron ions, which is applied in the direction of surgical drugs, drug combinations, drug delivery, etc., can solve the problems that the prevention of adhesion can not achieve the desired effect, and the retention time is short, so as to achieve long retention time and solve anti-adhesion , good biocompatibility

Inactive Publication Date: 2004-02-11
YINYI BIOLOGICAL MATERICAL RES & DEV DALIAN
View PDF0 Cites 27 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the short retention time of natural hyaluronic acid at the implant site, its adhesion prevention effect cannot achieve the desired effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The hyaluronic acid gel with medicine and iron ions for postoperative anti-adhesion, the preparation method is as follows:

[0036] (1) adding hyaluronic acid into deionized water to prepare a hyaluronic acid solution with a mass percentage of 1%, and fully stir until dissolved;

[0037] (2) FeCl 3 Add 1M HCl to configure FeCl with a mass volume concentration of 1.5% 3 solution;

[0038] (3) Add 1M HCl dropwise to the hyaluronic acid solution while stirring to fully mix the two until the pH value reaches 4.75;

[0039] (4) FeCl with a volume ratio of 3:10 to the above solution 3 The solution was added dropwise to the above solution, fully stirred for 10-20min;

[0040] (5) Add 1M NaOH dropwise to the above solution until the solution becomes a gel and the pH value is 7;

[0041] (6) The above-mentioned gel is freeze-dried and pressed into powder;

[0042] (7) Put the above-mentioned powder into a disinfection cabinet and disinfect it with ozone for 2 times;

[00...

Embodiment 2

[0046] The hyaluronic acid gel with medicine and iron ions for postoperative anti-adhesion, the preparation method is as follows:

[0047] (1) adding hyaluronic acid into deionized water to prepare a hyaluronic acid solution with a mass percentage of 1%, and fully stir until dissolved;

[0048] (2) FeCl 3 Add 1M HCl to configure FeCl with a mass volume concentration of 1.5% 3 solution;

[0049] (3) Add 1M HCl dropwise to the hyaluronic acid solution while stirring to fully mix the two until the pH value reaches 4.75;

[0050] (4) FeCl with a volume ratio of 3:10 to the above solution 3 The solution was added dropwise to the above solution, fully stirred for 10~20min;

[0051] (5) Add 1M NaOH dropwise to the above solution until the solution becomes a gel and the pH value is 7;

[0052] (6) The above-mentioned gel is freeze-dried and pressed into powder;

[0053] (7) UV irradiation of the above-mentioned powder;

[0054] (8) Mix the above powder and Tranister drug powder...

Embodiment 3

[0056] The hyaluronic acid gel with medicine and iron ions for postoperative anti-adhesion, the preparation method is as follows:

[0057] (1) adding hyaluronic acid into deionized water to prepare a hyaluronic acid solution with a mass percentage of 1%, and fully stir until dissolved;

[0058] (2) FeCl 3 Add 1M HCl to configure FeCl with a mass volume concentration of 1.5% 3 solution;

[0059] (3) Add 1M HCl dropwise to the hyaluronic acid solution while stirring to fully mix the two until the pH value reaches 4.75;

[0060] (4) FeCl with a volume ratio of 3:10 to the above solution 3 The solution was added dropwise to the above solution, fully stirred for 10~20min;

[0061] (5) Add 1M NaOH dropwise to the above solution until the solution becomes a gel and the pH value is 7;

[0062] (6) The above-mentioned gel is freeze-dried and pressed into powder;

[0063] (7) Put the above powder into Co 60 irradiation disinfection;

[0064] (8) Mix the above powder and Traniste...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a novel adhesion preventing agent with wide application in preventing post-operation adhesion. The present invention features that under acid condition, hyaluronic acid and ferric chloride are mixed for full crosslinking to form iron crosslinked hyaluronic acid derivative with increased molecular weight and prolonged degradation period, and organic high molecular matter capable of suppressing collagen synthesis is then added to further strengthen the adhesion preventing effect. The adhesion preventing biological material of the present invention has good biocompatibility and long retention period inside body, and can prevent post-operation adhesion effectively before degrading automatically into harmless matter.

Description

[0001] Field [0002] The invention belongs to a novel anti-adhesion agent, in particular hyaluronic acid gel with medicine and iron ions for anti-adhesion after operation, and has a very wide application in the field of preventing tissue adhesion after operation. Background technique [0003] 1. The cause of anti-blocking agent [0004] The development of anti-adhesion agents originated from the medical profession's concern about post-surgical adhesions. Adhesions increase the difficulty of reoperation and the potential risk of further complications. Therefore, in-depth exploration of the causes of adhesion formation to prevent and reduce postoperative adhesions has become a key research direction in the field of surgery today. At present, there are two commonly used methods for reducing adhesions: 1) direct perfusion of various substances to reduce or inhibit the formation of fibrous connective tissue (Wiseman D. Polymers for the prevention of surgical adhesions. In: Domb ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/00A61K31/728A61P41/00
Inventor 崔福斋田维明张存理俞兴董保彦
Owner YINYI BIOLOGICAL MATERICAL RES & DEV DALIAN
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com