Building animal model of asthenopia based on tupaia belangeri as experiment animal

A technology of animal models and experimental animals, applied in the field of animal models

Inactive Publication Date: 2004-03-10
张堰黎
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far no ciliary muscle β-AR (mostly β 2 -AR), M-ACh receptors in the pupillary sphincter (mostly M 3 -ACh receptor), and its second messenger system are used as objective indicators to evaluate animal models of visual fatigue, screen new drugs for preventing and treating visual fatigue, and evaluate literature reports on methods for preventing and treating visual fatigue.

Method used

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  • Building animal model of asthenopia based on tupaia belangeri as experiment animal
  • Building animal model of asthenopia based on tupaia belangeri as experiment animal
  • Building animal model of asthenopia based on tupaia belangeri as experiment animal

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Force the tree shrew's eyes to overuse adjustment (positive adjustment) method by using lures:

[0019] Adult tree shrews were selected, and the tree shrews with normal eyes and general condition were randomly divided into model group and normal control group.

[0020] Normal control group: the tree shrews were placed in a cage with a sleeping box, the sleeping box was open, and the animals could come in and out freely. Food and water were given 2 times a day. Normal light during the day; no light at night.

[0021] Model group: the tree shrews were placed in a cage with a sleeping box. The sleeping box was closed every day (7:00-19:00), and the tree shrews could only move outside the sleeping box. The distance is continuously lured; the sleeping box in the tree shrew cage is open at night (19:00 to 7:00 the next day), and the tree shrew can enter the sleeping box to rest during this period. Feed and water 2 times a day. Normal light during the day; no light at nigh...

Embodiment 2

[0025] Place the goggles in front of the eyes with a light-emitting Class II tube stimulator for continuous stimulation, forcing the tree shrews to overuse the adjustment (positive adjustment) method:

[0026] Adult tree shrews were selected, and the tree shrews with normal eyes and general condition were randomly divided into model group and normal control group.

[0027] Normal control group: the tree shrews were placed in a cage with a sleeping box, the sleeping box was open, and the animals could come in and out freely. Give food and drink water 2 times a day. Normal light during the day; no light at night.

[0028] Model group: tree shrews were placed in a cage with a sleeping box, and the sleeping box was closed every day (7:00 to 19:00), the tree shrews could only move outside the sleeping box, and an eye mask was placed in front of the tree shrews to emit light II The stage tube stimulator was used for continuous stimulation; the sleeping box in the tree shrew cage w...

Embodiment 3

[0032] By wearing a concave lens in front of the eyes, the tree shrew's eyes are forced to use the adjustment (positive adjustment) method:

[0033] Adult tree shrews were selected, and the tree shrews with normal eyes and general condition were randomly divided into model group and normal control group.

[0034] Normal control group: the tree shrews were placed in a cage with a sleeping box, the sleeping box was open, and the animals could come in and out freely. Give food and drink water 2 times a day. Normal light during the day; no light at night.

[0035] Model group: tree shrews were placed in a cage with a sleeping box, and the sleeping box was closed every day (7:00 to 19:00), the tree shrews could only move outside the sleeping box, and a concave lens was placed in front of the tree shrews. Force the tree shrew's eyes to overuse adjustment (positive adjustment); the sleeping box in the tree shrew cage is opened at night (19 o'clock to 7 o'clock the next day), and th...

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Abstract

Forcing eyes of tupaia belangeri to be adjusted overly (positive adjustment) makes parasympathetic nerves, which controls eye adjustment, erethism. Thus, excitability of sympathetic nerve is changed correspondingly; ciliary muscle and sphincter pupillae are durative shrinked so as to cause dynamic dysequilibrium between sympathetic nerve and parasympathetic nerves for adjusting eyes. Asthenopia model of tupaia belangeri is built thorugh experimental media. The model can be utilized to study pathogenesis, prevent and treat asthenopia, filtrate out new drug and evaluate method for treating asthenopia.

Description

technical field [0001] The invention belongs to the technical field of medical evaluation and detection, and in particular relates to an animal model constructed by using tree shrew (Tupaia Belangeris, TreeShrew) as an experimental animal for studying the pathogenesis of visual fatigue and conducting research on prevention and treatment of visual fatigue. technical background [0002] Asthenopia is also known as eye tension and eye fatigue (eye-strain, eye-fatigue). Chinese medicine calls it "liver fatigue". The word asthenopia is derived from the Greek expression, which originally means "weak eye". Relevant epidemiological studies have shown that: with the change of information exchange methods and the accelerated pace of work, the number of people with visual fatigue has gradually increased in recent years, especially among people who use video display terminals such as computers, TVs, monitors, and electronic game consoles. At the same time, 66% of myopia patients show ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G09B23/36
Inventor 张堰黎
Owner 张堰黎
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