Preparation process of the freeze drying protective agent for the vaccin used for animals

Abstract

A method of preparing lyophilizing protectant for animal vaccines. It comprises adding injecting water and heating, adding ketopyrrolidine glutin and stirring, adding bisodium hydrogen phosphate withtwelve crystallized water ,dipotassium hydrogen phosphate, sodium chloride, cane sugar, monosodium glutamate and potassium chloride, and stirring, adjusting pH to 7.0í½7.2, disinfecting at high pressure. The lyophilizing protectant could make vaccines store at 2í½8degree C for over 18 months.

Description

technical field [0001] The invention belongs to the technical field of biological products, in particular to a preparation method of a vaccine freeze-drying protectant for animals. Background technique [0002] In recent years, my country's animal husbandry has developed rapidly, and the per capita amount of meat and eggs ranks first in the world. The current stock of chickens reaches 10 billion, and the stock of pigs reaches 800-100 million. More than 120 kinds of freeze-dried vaccines are needed every year, more than 500 billion (head) copies, and the sales volume reaches more than 3 billion yuan. At present, freeze-dried vaccines in my country need to be stored at low temperature (below -15°C), while foreign freeze-dried vaccines only need to be stored at 2-8°C, which saves a lot of storage and transportation costs, and the vaccine preservation effect is good. The main difference is the difference in the lyoprotectant. At present, the freeze-dri...

AI Technical Summary

Problems solved by technology

At present, the freeze-dried protective agent for vaccines in my country is 5% sucrose skimmed milk. This protective agent is low in cost and easy to prepare, but it must be stored below -15°C. The storage period of the vaccine is short, the storage effect is not ideal, the transportation is troublesome, and the storage and transportation costs are high.

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