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Method for preparing nanometre structure medicine

A nanostructure and drug technology, applied in the directions of pharmaceutical formulations, medical preparations of inactive ingredients, liposome delivery, etc., can solve the problems of affecting the preparation effect, a large number of foams, difficult to solve, etc., and achieve a simple, convenient and repeatable preparation process. High performance and improved stability

Inactive Publication Date: 2004-04-21
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] NLC prepared by single high-shear homogeneous treatment has certain problems in product stability and other aspects, which are difficult to solve
Moreover, because there are many emulsifiers in the raw materials, when some systems are processed, a large amount of foam will often be generated, which will affect the preparation effect.

Method used

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  • Method for preparing nanometre structure medicine
  • Method for preparing nanometre structure medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1. Mix 0.2 grams of oil phase (containing 0.16 grams of soybean oil and 0.04 grams of stearic acid) with 1.0 grams of Span 80, heat to 65°C to become a molten liquid, and add 2.0 milligrams of retinoic acid to dissolve.

[0028] 2 Add the mixture obtained in step 1 into 150 ml of distilled water at 65°C, and simultaneously use a high-shear homogenizer for high-shear treatment to obtain colostrum.

[0029] 3 Dissolve 3.0 g of Tween 80 in 50 ml of distilled water and heat to 65°C, add colostrum, stir with a magnetic stirrer for 10 minutes, and then use an ultrasonic cleaner for 30 minutes of ultrasonic treatment.

[0030] 4 Put the mixture obtained in step 3 in a separatory funnel and let it stand for 12 hours, take out the lower layer and freeze-dry it to obtain the desired NLC.

Embodiment 2

[0032] 1 1.0 g of oil phase (containing 0.8 g of soybean oil and 0.2 g of stearic acid) is mixed with 1.0 g of Span 80, heated to 65°C to become a molten liquid, and 8.0 mg of retinoic acid is added to dissolve.

[0033] 2 Add the mixture obtained in step 1 into 150 ml of distilled water at 65°C, and simultaneously use a high-shear homogenizer for high-shear treatment to obtain colostrum.

[0034] 3 3.0 g of Tween 80 was dissolved in 150 ml of distilled water and heated to 65°C, then added colostrum, stirred with a magnetic stirrer for 30 minutes, and then ultrasonically treated with an ultrasonic cleaner for 60 minutes.

[0035] 4 Put the mixture obtained in step 3 in a separatory funnel and let it stand for 24 hours, take out the lower layer and freeze-dry it to obtain the desired NLC.

Embodiment 3

[0037] 1. Mix 0.5 grams of oil phase (containing 0.4 grams of peanut oil and 0.1 grams of stearic acid) with 1.0 grams of Span 80, heat to 65°C to become a molten liquid, and add 6.0 milligrams of retinoic acid to dissolve.

[0038] 2 Add the mixture obtained in step 1 into 150 ml of distilled water at 65°C, and simultaneously use a high-shear homogenizer to perform high-shear treatment to obtain colostrum.

[0039] 3 3.0 g of Tween 80 was dissolved in 50 ml of distilled water and heated to 65°C, then added colostrum, stirred with a magnetic stirrer for 20 minutes, and then ultrasonically treated with an ultrasonic cleaner for 40 minutes.

[0040] 4 Put the mixed solution obtained in step 3 in a separatory funnel and let it stand for 18 hours, take out the subnatant and freeze-dry it to obtain the desired NLC.

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Abstract

A process for preparing the lipoid medicine carrier with nano structure includes such steps as proportioning plant oil and fatty acid or glycerine ester of fatty acid, mixing to obtain oil phase, proportionally mixing it with span-type emulsifier, heating to 60-80 deg.C, adding medicine, fusing, adding it to water, high-shear homogenizing, adding the hot tween-type emulsifier solution to it, stirring for 10-30 min, ultrasonic treating, depositing, taking supernatant and freeze drying.

Description

1. Technical field: [0001] The invention is a preparation method of nano medicine, especially a preparation method of nano structure lipid carrier. 2. Background technology: [0002] Solid Lipid Nanoparticles (SLN) is a new nanoscale drug carrier developed in the 1990s. SLN has attracted extensive attention of researchers because it overcomes many shortcomings of nanoemulsions and polymer nanoparticles. SLN mainly solves the formulation problems of some fat-soluble drugs. However, SLN also has shortcomings, one of which is the destruction of the drug carrier structure caused by the crystallization of a single lipid material as a carrier. In order to solve this problem, nanostructured lipid carriers (NLC) came into being. [0003] The biggest advantage of NLC is that it effectively avoids the shortage of a single solid lipid material extruding the drug out of the carrier due to crystallization. The carrier material of NLC is a mixture of liquid lipid and solid lipid mater...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K47/00A61K47/44
Inventor 夏强顾宁张晓佳
Owner SOUTHEAST UNIV
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