Notoginseng drop pills for calming nerve and curing insomnia etc. and preparation method

A technology of Aescin and dripping pills, which is applied in the field of pharmaceuticals, can solve the problems of affecting the health of production workers, unstable main drug efficacy, and slow dissolution rate of tablets, and achieves benefits for labor protection, easy control of preparation conditions, and dissolution fast speed effect

Inactive Publication Date: 2004-06-02
金七药业股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dissolution rate of the tablet is slow in clinical application and the bioavailability is poor
The production process requires hot and humid operation, which affects the efficacy of some unstable main drugs; and requires skilled operators to operate, and due to changes in people's technical quality and energy, it is easy to cause large fluctuations in the quality of different batches of drugs; dust in the production process Flying, affecting the health of production workers

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Use the ratio of notoginsin: water-soluble matrix polyethylene glycol 6000=1:2 to select raw materials, and prepare according to the following steps:

[0083] 1) Grind notoginseng leaf glycosides, pass through a 180-mesh sieve into a container, add an appropriate amount of distilled water, stir evenly in a water bath at 80°C, and set aside;

[0084] 2) Take the water-soluble matrix polyethylene glycol 6000 and melt it in the 80°C water bath built in the container, slowly add the spare materials in the above 1) under constant stirring, mix well and pour it into the preheated dropping pill machine, the temperature At 80°C, drop it into the cooled fat-soluble condensing agent liquid paraffin at a rate of 50 drops per minute to make drop pills, select the pills, and pack them.

Embodiment 2

[0086] Use notoginsin: the ratio of water-soluble matrix polyethylene glycol 4000=1:1 to select raw materials, and prepare according to the following steps:

[0087] 1) Grind notoginseng leaf glycosides into fine powder, pass through a 180-mesh sieve into a container, add an appropriate amount of distilled water, stir evenly in a water bath at 90°C, and set aside;

[0088] 2) Take the water-soluble matrix polyethylene glycol 4000 and dissolve it in a 90°C water bath built in the container, slowly add the spare ingredients in the above 1) under constant stirring, mix well and pour it into the preheated dropping pill machine, At a temperature of 75°C, drip into the cooled fat-soluble condensing agent methyl silicone oil at a rate of 60 drops per minute to make drop pills, select the pills, and pack them.

Embodiment 3

[0090] Use the ratio of notoginsin: water-soluble matrix polyethylene glycol 6000=1:5 to select raw materials, and prepare according to the following steps:

[0091] 1) Take notoginseng leaf glycosides and grind them finely, pass through a 180-mesh sieve into a container, add an appropriate amount of distilled water, stir evenly in a water bath at 100°C, and set aside;

[0092] 2) Take the water-soluble matrix polyethylene glycol 6000 and dissolve it in a 100°C water bath built in the container, slowly add the spare materials in the above 1) under constant stirring, mix well and pour it into the preheated dropping pill machine, the temperature At 90°C, drop it into the cooled fat-soluble condensing agent liquid paraffin at a rate of 70 drops per minute to make drop pills, select the pills, and pack them.

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PUM

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Abstract

The tranquilizing Qiye dripping pill is prepared with arasaponin and water soluble matrix in the ratio of 1 to 1-5 and through mixing, water bath treatment, dissolving, dropping into condensing agent. The tranquilizing Qiye dripping pill has the functions of benefiting vital energy, tranquilizing mind, promoting blood circulation, stopping pain and hypnogenesis, and thus has excellent insomnia treating effect. The preparation process of the present invention has high medicine quality, high bioavailability and many other advantages.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to Qiye Shen'an dripping pills for mainly treating insomnia and other diseases and a preparation method thereof. Background technique [0002] Now on the market, "Qicye Shen'an Tablet" has been clinically verified for many years, with definite curative effect and stable dosage form. However, the dissolution rate of tablets in clinical application is slow and their bioavailability is poor. The production process requires hot and humid operation, which affects the efficacy of some unstable main drugs; and requires skilled operators to operate, and due to changes in people's technical quality and energy, it is easy to cause large fluctuations in the quality of different batches of drugs; dust in the production process Flying, affecting the health of production workers. Contents of the invention [0003] The purpose of the present invention is to provide a kind of Chiye Shen'an dr...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/704A61P25/20
Inventor 王兰张云生王会
Owner 金七药业股份有限公司
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