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Burnet general saponin extract , its preparation method and use

A technology of saponins and total saponins of Burnet elm, which is applied in the direction of medical formula, drug combination, drug delivery, etc., to achieve good effect of increasing white blood cells, convenient use, and remarkable curative effect

Active Publication Date: 2004-06-16
CHENGDU DIAO PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Further studies have found that the tannins and polyphenols contained in Burnet have strong hemostatic effects, but there are few studies on the saponins of Burnet and their activities, and there is no total saponin extract of Burnet and its treatment of white blood cells. Relevant literature records or research reports of hypothalamus

Method used

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  • Burnet general saponin extract , its preparation method and use
  • Burnet general saponin extract , its preparation method and use
  • Burnet general saponin extract , its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: Preparation of Burnet Burnet total saponins extract

[0034] Burnet 1000g, crushed, add 8L of 70% ethanol solution, heat and reflux for extraction for 1.5 hours, add 6L of 70% ethanol solution to the filter residue, heat and reflux for extraction for 1 hour, and filter. Combine the two filtrates, concentrate to a certain concentration, and set aside for later use. Take the polyamide column, absorb the above extract with a polyamide column, then elute the column with ethanol with a concentration of 70%, collect the eluent, recover the ethanol from the eluent under reduced pressure to obtain an extract, add water to heat to dissolve, and then The polyamide column was repeatedly adsorbed once, and finally the extract was obtained, which was vacuum-dried into a dry powder to obtain 24 g of total saponins extract of Burnet burnet, the total saponin content of which was 55% of the total weight.

Embodiment 2

[0035] Embodiment 2: Burnet Burnet total saponins extract to 60 Protective effect of Co-γ-induced bone marrow injury in mice

[0036] 60 Kunming mice, half male and half female, are divided into 6 groups: normal control group, model control group, high, middle and low dose groups of total saponins extract from Burnet burnet (total saponin extract from Burnet burnet obtained in Example 1) , batyl alcohol group. The above 6 groups of animals, except the normal control group animals, the other 5 groups of animals were treated with 1 day before administration. 60 Co-γ ray was irradiated once, with a dose of 4Gy. After 24 hours, they were randomly divided into 5 groups. Except for the normal control group and the model control group, 0.4ml of distilled water was administered intragastrically, and the rest of the groups were intragastrically administered with different doses. 1 time, for 7 consecutive days. 24 hours after the last administration, the mouse eyeball was pulled out ...

Embodiment 3

[0040] The results in Table 1 show that each dose of the total saponins extract of Burnet burnet has a very significant or significant difference compared with the model control group, that is, the total saponins of Burnet burnet extract has a significant effect on 60 External application of leukopenia caused by Co-γ irradiation has a significant protective effect, and the curative effect of the large and medium dose groups is better than that of the positive control drug batyl alcohol group. Example 3: Therapeutic effect of total saponins extract from Burnet burnet on leukopenia in mice induced by cyclophosphamide

[0041] 67 Kunming mice, half male and half male, are randomly divided into 6 groups, i.e. normal control group, cyclophosphamide model control group (Cy group), Cy+ Burnet burnet total saponins extract (for embodiment 1 gained Burnet burnet total saponins extract) high, medium and low dose groups, Cy+bakelyl alcohol group. Except for the normal control group, mic...

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Abstract

The invention relates to a sanguisorba root general saponin extract, method for preparation and use thereof, characterized in that, a sanguisorba root general saponin extract is provided which contains sanguisorba root general saponin, the percentage by weight is 10-90%, it can be utilized in the preparation of medicinal preparation for treating or preventing human leucocytopenia. The beneficial effects of the invention are, the preparation can be made into multiple doses including oral, tablet and capsule, and it is adapted for leucocytopenia of unknown reasons.

Description

technical field [0001] The present invention relates to a traditional Chinese medicine extract and its preparation method and use, in particular, to a Burnet eucalyptus total saponin extract and its preparation method, as well as its use in the preparation of pharmaceutical preparations for the treatment or prevention of human leukopenia . Background technique [0002] Judging from the world's population spectrum and disease spectrum, tumors are extremely harmful to human health, and its incidence is increasing year by year, while its mortality rate ranks first among many diseases. In the treatment of tumors, the comprehensive drug therapy based on radiotherapy and chemotherapy is still the main means and methods of tumor treatment. However, radiotherapy and chemotherapy itself have obvious toxic and side effects that are difficult to overcome. The main side effect is the inhibition of bone marrow hematopoietic function, which is manifested as a significant decrease in whit...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/10A61K9/20A61K9/48A61K31/56A61P7/00A61P35/00C07J63/00
Inventor 邹文俊刘忠荣付铁军刘豫及元乔王若竹喻凯
Owner CHENGDU DIAO PHARMA GROUP
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