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Sustained releasing talbets for radioactive and chemical therpay and preparation thereof

A technology of sustained-release pellets and sustained-release coating, which is applied in the field of sustained-release pellets and their preparation, and can solve the problems of affecting the therapeutic effect and being unable to maintain for a long time.

Inactive Publication Date: 2004-09-22
潘伟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The usual oral dose of ondansetron is 8mg / time, 3 times / day, pharmacokinetic studies show that the terminal elimination half-life of ondansetron in human body is 2.5-5.4h, so it cannot maintain the drug in the human body for a long time. The effective concentration affects the therapeutic effect of the drug

Method used

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  • Sustained releasing talbets for radioactive and chemical therpay and preparation thereof
  • Sustained releasing talbets for radioactive and chemical therpay and preparation thereof

Examples

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preparation example Construction

[0037] The preparation method of the sustained-release pellets for treating radiotherapy and chemotherapy vomiting of the present invention consists of the following steps in turn:

[0038] (1) Preparation of pill core

[0039] Method 1: Pass the raw drug through a 100-mesh sieve, mix it with microcrystalline cellulose by equal volume incremental dilution method, and then mix it with lactose. Add appropriate amount of distilled water to make a soft material, make pellets on an extrusion spheronizer, dry at 55°C for 3 hours, and sieve 18-24 mesh pellets for coating.

[0040] Method Two:

[0041] (a) Preparation of drug-containing layer coating suspension

[0042] (1) Preparation of suspension: Soak 2-10 grams of hydroxypropyl methylcellulose in 20-120 ml of 80-90 ° C distilled water for 2-8 hours, then add 0.2-10 grams of anti-sticking agent and 100-180 ml of 95% ethanol , stir evenly, and filter through a 200-mesh sieve.

[0043] (2) Preparation of drug-containing coating ...

Embodiment 1

[0062] (1) Preparation of pill core

[0063] See the preparation method 1 of the pill core.

[0064] (2) Preparation of drug-free sealing layer

[0065] Preparation of the suspension: Soak 2 g of hydroxypropyl methylcellulose in 20 ml of 80-90° C. distilled water for 2 hours, then add 0.2 g of anti-sticking agent and 100 ml of 95% ethanol, stir evenly, and filter through a 200-mesh sieve.

[0066] After 50 g of pill cores were dried at 50° C., 5 ml of suspension fluidized bed spray coating was applied to blank pellet cores, and then dried.

[0067] (3) Preparation of sustained-release coating solution

[0068] Dissolve 2.4g of porogen in water, then add 1.8g of anti-sticking agent and 16g of acrylic resin aqueous dispersion (NE30D), and add water to 60g. Stir evenly and filter through a 200-mesh sieve.

[0069] (4) Preparation of sustained-release coating layer

[0070] Use 18ml of slow-release coating solution, continue to spray coating in the ebullating bed at 23°C, and...

Embodiment 2

[0074] (1) Preparation of pill core

[0075] (1) Preparation of drug-containing layer coating suspension

[0076] (a) Preparation of suspension: Soak 2 g of hydroxypropyl methylcellulose in 20 ml of 80-90° C. distilled water for 2 hours, then add 0.2 g of anti-sticking agent and 100 ml of 95% ethanol, stir evenly, and filter through a 200-mesh sieve.

[0077] (b) Preparation of drug-containing coating suspension: add 4.5 g of ondansetron to 55 ml of 95% ethanol to dissolve, then add 6.0 ml of the suspension, and stir evenly.

[0078] (2) Preparation of drug-containing sealing layer

[0079] Adopt the model that NP PHARM company produces to be the blank ball core 50 grams of PF008 after drying, 63ml drug-containing layer coating suspension is spray-coated on the blank ball core, then dry again.

[0080] (2) Preparation of drug-free sealing layer

[0081] Containing 50 g of pill cores, after drying, 63 ml of suspension fluidized bed spray coating is applied to blank ball core...

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Abstract

A slow-releasing micropill 'Angdansiqiong' for treating the vomiting caused by chemicotherapy or radiotherapy is composed of pill core, enclosing layer, slow-releasing layer and surficial enclosing layer. It is prepared from Angdansiqiong as core (6.4-7.8 wt.%), acrylic resin (3.1-3.8), pore-forming agent (0.5-1.1), antisticking agent (0.6-1.1) and filler (86.2-89.3). Its advantages are durable action (more than 24 hr) and high curative effect.

Description

technical field [0001] The invention relates to a slow-release pellet for treating emesis during radiotherapy and chemotherapy and a preparation method thereof. Background technique [0002] Treatment of cancer with radiation or chemotherapy often comes with unpleasant side effects, nausea and vomiting are overwhelming and frightening for patients. Nausea and vomiting after chemotherapy can be divided into three types: acute, chronic and predictable. Ondansetron is 5-HT 3 A strong selective blocker of receptors, has pre-radiation and therapeutic effects on the above nausea and vomiting. [0003] At present, the commonly used dosage forms of the drug include injections, ordinary tablets, and capsules. Once the patient vomits, frequent administration is required, which brings trouble to both the patient and the nursing staff. The sustained and controlled release preparation can reduce the number of administrations, thereby Increase patient compliance. Therefore, it will be ...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K9/28A61K31/4178A61P1/08
Inventor 潘伟潘勇张喜荣
Owner 潘伟
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