Vermis expelling resinate and its preparation
A technology of anthelminth and resin, applied in the fields of praziquantel and exetel, which can solve the problems of strong sting, reluctance to eat, and high cost of capturing and injecting wild animals
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Embodiment 1
[0057] The praziquantel is loaded on the cation exchange resin. - The resin used in this example is a weakly acidic methacrylic acid cation exchange resin with an exchange capacity of about 10.6 meq / g. Water (5.63 kg) and 95% ethanol (1.88 kg) were charged to a 10 liter flask equipped with a stirrer. The stirrer was started and resin (1.5 kg) was slowly added followed by praziquantel (175 g). When the praziquantel is fully dispersed, adjust the stirring speed to maintain the resin and praziquantel in a good suspension state. Stir overnight. After the stirring was stopped, the supernatant was removed by filtration. An additional 3.5 kg of water was added to the resin, the mixture was stirred for 5 minutes, and then the supernatant was removed by filtration. The washing step was repeated two more times. The resin is dried in a vacuum oven at 60-70 degrees Celsius until the water content is less than 5% w / w. The dried resin contained 9.9% w / w praziquantel based on mass bala...
Embodiment 2
[0059] Praziquantel release from resinate. - The resinate used in this example was prepared in a manner similar to Example 1 except that the resinate was not tested on drying. This resinate contained 9.3% w / w praziquantel (calculated on dry weight). To 10 ml of a solution containing the following components was added 273.3 mg of resinate:
[0060] 5.0% NaHCO 3
[0061] 2.35% NaCl
[0062] 0.75% KCl
[0063] Sufficient hydrochloric acid was added to adjust the pH to 7.0.
[0064] The mixture was shaken overnight. Observation of the mixture revealed the appearance of a white precipitate, which was confirmed to be praziquantel. Analysis of praziquantel in the supernatant revealed that the concentration of praziquantel was close to its saturation. This example shows that praziquantel is released from the resin at near neutral pH (resin is ionized).
Embodiment 3
[0066] Loading of praziquantel onto anion exchange resin. - The resin used in this example is a weakly basic anion exchange resin which exists in the free base form. This resin has an exchange capacity of about 10 meq / g. Add 100 mg of praziquantel to 15 g of 95% ethanol and shake until dissolved. Then 45 g of water were added thereto, followed by 3.1 g of resin (well hydrated). The mixture was shaken overnight at room temperature and filtered. The resulting resin contained 5.4% praziquantel (calculated on dry weight).
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