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Yinzhihuang powder injection and its preparation process

A technology of Yinzhi and yellow powder, applied in the field of medicine, can solve the problems of high impurity content, many adverse reactions, poor stability of active ingredients, etc., and achieve the effects of less impurity content, small adverse reactions and high stability

Inactive Publication Date: 2004-11-10
上海博泰医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The technology of aqueous injection is relatively backward, the stability of active ingredients is poor, and the content of impurities is high, causing more adverse reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] capillary extract or its salt 12g

[0014] Gardenia extract or its salt 6.4g

[0015] Baicalin or its salt 40g

[0016] Honeysuckle extract or its salt (calculated as chlorogenic acid) 8g

[0017] Mannitol 66.4g

[0018] A total of 1000 pieces were made

[0019] Preparation method: take baicalin or its salt, add water to moisten it, and dissolve it with sodium hydroxide solution; add water to dissolve the other capillary extracts and other three flavors, and add mannitol to dissolve, mix well, adjust the pH value, and dilute with water for injection To 2000ml, add activated carbon to absorb, filter, sub-package, freeze-dry, and melt seal.

[0020] Note: 1. Capillaris extract is the 90% ethanol percolation extract of capillary, removes oils such as chlorophyll, and is a solid extract obtained by drying under reduced pressure.

[0021] 2. Gardenia jasmine extract is the 70% ethanol reflux extract of Gardenia jasminoides, precipitated with 95% ethanol, and dried under...

Embodiment 2

[0025] capillary extract or its salt 22g

[0026] Gardenia extract or its salt 6.4g

[0027] Baicalin or its salt 40g

[0028] Honeysuckle extract or its salt (calculated as chlorogenic acid) 16g

[0029] Accessories 0

[0030] A total of 1000 pieces were made

[0031] Preparation method: Take the extract of Siwei, add appropriate amount of water, dissolve it with sodium hydroxide solution, adjust the pH value, dilute it with water for injection to 2000ml, add activated carbon for adsorption, filter, spray dry, sub-package, and melt seal.

Embodiment 3

[0033] capillary extract or its salt 80g

[0034] Gardenia extract or its salt 12g

[0035] Baicalin or its salt 5g

[0036] Honeysuckle extract or its salt (calculated as chlorogenic acid) 7g

[0037] Accessories 32g

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PUM

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Abstract

The invention relates to a medicament for heat-clearing, detoxification and removing dampness, which comprises capilary Artemisia extractive or its salt, cape jasmine extract or its salt, baicalin or its salt, honeysuckle flower extract or its salt and water-soluble medicinal findings.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a pharmaceutical preparation of Yinzhihuang, more specifically to a Yinzhihuang powder injection, and simultaneously the invention also relates to a preparation method of the preparation. Background technique [0002] "Yinzhihuang" is a famous prescription in Chinese traditional medicine. In traditional Chinese medicine, it has the functions of clearing away heat, detoxification, dampness and yellowing. For liver and gallbladder damp heat, yellow complexion, distending pain in chest and hypochondrium, nausea and vomiting, yellow and red urine, acute, persistent and chronic hepatitis embolism. At present, the clinical preparations of "Yinzhihuang" mainly include water for injection injections and tablets. The technology of aqueous injection is relatively backward, the stability of active ingredients is poor, and the content of impurities is high, causing more adverse reactions. ...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61P1/16
Inventor 张卫东苏娟张川杨杰
Owner 上海博泰医药科技有限公司
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