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Nanometer preparation of natural vitamin E and its preparation

A natural vitamin and nano-preparation technology, applied in the field of natural vitamin E nano-preparation and its preparation, can solve the problems of low bioavailability and poor absorption

Inactive Publication Date: 2004-11-17
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when vitamin E, which is a fat-soluble drug, is used in the above-mentioned dosage forms, like other fat-soluble drugs, it has the disadvantages of low bioavailability and poor absorption to varying degrees.

Method used

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  • Nanometer preparation of natural vitamin E and its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 1. Weigh 0.5 g of stearic acid and 0.15 g of soybean lecithin, heat to 75°C and mix evenly to obtain a liquid oil phase;

[0036] 2. Weigh 0.1 g of natural vitamin E and add it to the liquid oil phase, stir and mix evenly to obtain a clarified system;

[0037] 3. Weigh 2.0g of S-40, dissolve it in 100ml of water, and heat to 75°C;

[0038] 4. Add the clarification system obtained in step 2 into 100 ml of water at 75°C, mix well, and emulsify with magnetic stirring equipment and ultrasonic treatment equipment for 30 minutes and 10 minutes;

[0039] 5. Cool to room temperature to obtain the solid lipid nanoparticles of natural vitamin E.

Embodiment 2

[0041] 1. Weigh 6 grams of stearic acid, 4 grams of soybean oil, and 1.5 grams of soybean lecithin, and heat to 75 ° C to mix evenly to obtain a liquid oil phase;

[0042] 2. Weigh 1.0 g of natural vitamin E and add it to the liquid oil phase, stir and mix evenly to obtain a clarified system;

[0043] 3. Weigh 10 grams of S-40, dissolve it in 1000 ml of water, and heat to 75°C;

[0044] 4. Add the clarification system obtained in step 2 into 1000 ml of water at 75°C, mix well, and emulsify with a high-pressure homogenizer for 3 minutes;

[0045] 5. Cool to room temperature to obtain the nanostructured lipid carrier of natural vitamin E.

Embodiment 3

[0047] 1. Weigh 5 grams of soybean oil and 0.75 grams of soybean lecithin, heat to 60 ° C and mix evenly to obtain a liquid oil phase;

[0048] 2. Weigh 0.5 grams of natural vitamin E and add it to the liquid oil phase, stir and mix evenly to obtain a clarified system;

[0049] 3. Heat 500ml of water to 60°C;

[0050] 4. Add the clarification system obtained in step 2 into 500 ml of water at 75°C, mix well, and emulsify with a high-pressure homogenizer for 2 minutes;

[0051] 5. Cool to room temperature to obtain the nanoemulsion of natural vitamin E.

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Abstract

The invention provides a natural vitamin E nano preparation and process for preparing it, wherein the ratio of grease material to emulsifying agent is 20:1 - 1:5, and the preparation process comprises mixing, heating, melting, charging natural vitamin E into the liquid oil phase, stirring to mix homogeneously, and carrying out emulsifying treatment.

Description

technical field [0001] The invention relates to a preparation method of nano-medicine and cosmetic raw materials, in particular to a natural vitamin E nano-preparation and a preparation method thereof. Background technique [0002] Vitamin E is a fat-soluble antioxidant, which can resist the damage of free radicals in the body and scavenge free radicals, inhibit the production of peroxides, and participate in various metabolic processes in the body. Vitamin E can enhance the blood flow of skin capillaries, increase the resistance of blood vessels to cold, maintain the normal permeability of capillaries, and delay the atrophy and degeneration of skin and some organs. Vitamin E, also known as tocopherol, can affect the reproductive function of human beings. At present, natural products can be prepared. For external use, it has the effects of moisturizing, protecting against ultraviolet rays, and slowing down the deposition of pigment or lipofuscin. ...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K9/14A61K31/355A61P3/02A61P39/06
Inventor 夏强顾宁马全红王以武
Owner SOUTHEAST UNIV
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