Lorazepam dripping pills and its preparation process

A dropping method and a technology for forming pills, which are applied in the field of lorazepam dropping pills and their preparation, can solve the problems of affecting the therapeutic effect of lorazepam, long disintegration time of lorazepam tablets, large proportion of excipients and the like. , to achieve the effect of convenient carrying and taking, small pill size, and reduced dosage of excipients

Inactive Publication Date: 2004-11-17
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Lorazepam tablets take a long time to disintegrate, have poor absorption, low bioavailability, and a large proportion of excipients. Children, the elderly, bedridden patients, and patients with dysphagia are inconvenient to take and have poor compliance, which affects the therapeutic effect of lorazepam. to play

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0020] prescription:

[0021] Lorazepam 1g

[0022] Polyethylene glycol 6000 19g

[0023] Makes 1000 capsules

[0024] Preparation method: Take the lorazepam fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone as a coolant, make pellets by drop method, and dry. have to.

example 2

[0026] prescription:

[0027] Lorazepam 1g

[0028] Macrogol 4000 19g

[0029] Makes 1000 capsules

[0030] Preparation method: Take the lorazepam fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone as a coolant, make pellets by drop method, and dry. have to.

example 3

[0032] prescription:

[0033] Lorazepam 1g

[0034] Macrogol 6000 9g

[0035] Macrogol 4000 10g

[0036] Makes 1000 capsules

[0037] Preparation method: Take the lorazepam fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 and polyethylene glycol 6000 mixed matrix, stir well, use simethicone as the coolant, drop The preparation method is to make pills, dry them, and obtain them.

[0038] 4. Example 4

[0039] prescription:

[0040] Lorazepam 1g

[0041] Glyceryl monostearate 19g

[0042] Makes 1000 capsules

[0043] Preparation method: Take lorazepam fine powder that has been superfinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate base, mix well, use ice water as a coolant, make pellets by drop method, and dry to obtain .

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PUM

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Abstract

The invention relates to a Lorazepum drop pill prepared by utilizing ultramicro disintegration and drop pill manufacturing process, which has the advantages of improving collapse and dissolving speed, quick effect, increased medicament stability, reduced adjuvant consumption, lowered production costs, and easiness in carrying and use. It has good compliance, thus is especially suitable for children, the elderly, bedridden patients and dysphagia patients.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to lorazepam dropping pills and a preparation method thereof. Background technique [0002] Lorazepam is a benzodiazepine, its effect is similar to that of diazepam, but its anti-anxiety effect is stronger than that of diazepam, and its sleep-inducing effect is obvious. Oral absorption is good and rapid. The binding rate with plasma protein is about 85%. Metabolized by the liver, the metabolites are biologically inactive. t 1 / 2 About 10 to 18 hours. After oral administration, the plasma concentration reaches the peak value within 1-4 hours; the steady-state plasma concentration is reached after 2-3 days. Clinically used for anxiety, insomnia and epilepsy. [0003] Lorazepam tablets take a long time to disintegrate, have poor absorption, low bioavailability, and a large proportion of excipients. Children, the elderly, bedridden patients, and patie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/5513A61P25/08A61P25/20A61P25/22
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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