New use of baicalin as medicine for treating anxiety neurosis
A new technology of baicalin, which is applied in the field of preparation of drugs for treating various anxiety diseases, can solve problems such as unseen treatments, and achieve the effect of avoiding central nervous system inhibition
Inactive Publication Date: 2004-11-24
PHARMACOGENETICS
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Clinically, there are no drugs and preparations containing baicalin as the main medicinal raw material for the treatment, control and relief of various anxiety symptoms.
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[0029] 1. γ-aminobutyric acid receptor (GABA) competitive binding baicalin assay results:
[0030] The radioimmunocompetitive binding method was used to determine the 50% stable binding concentration of compound baicalin in GABA receptor competitive inhibition (IC 50 ) and the competitive inhibition stable binding constant (K i ).
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Abstract
The present invention reveals the new medicinal use of baicalin as the effective medicinal components in skullcap root and stem and proposes the application of baicalin compound in treating various anxiety neurosis. It is proved that baicalin taken by mouse in the dosage of 7.5-30 mg / kg has obvious and reliable effect of resisting anxiety neurosis, so that the orally taken dosage for human is calculated to be 0.8-3.5 mg / kg. Baicalin is extracted from skullcap root and stem, has purity not lower than 97 %, and may be prepared into tablet, capsule, dripping pill, oral liquid, injection, etc. The present invention has outstand medicinal effect, low toxicity and low cost.
Description
technical field [0001] The invention relates to a new application of baicalin, an effective medicinal component in the rhizome of the Chinese herbal medicine Scutellaria baicalensis, for preparing medicines for treating various anxiety diseases. Background technique [0002] According to traditional Chinese medicine, Scutellaria baicalensis Georgi is the dry root of Labiatae plants. Cold in nature, bitter in taste, returns to lung; gallbladder; spleen; large intestine and small intestine meridians. Its medicinal functions are clearing away heat and dampness; purging fire and detoxifying; stopping bleeding; antiabortive. Traditional Chinese medicine is mostly used for damp heat, summer heat, chest tightness and nausea, damp heat and fullness, diarrhea and jaundice, cough due to lung heat, high fever and polydipsia, vomiting of blood heat at the nose, carbuncle sores and fetal restlessness. (Chinese Pharmacopoeia, the first 1995, pp.270) modern medical research proves: the m...
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IPC IPC(8): A61K31/7048A61K36/539A61P25/22C07D311/30
CPCA61K36/539A61P25/22
Inventor 薛红郑辉王子晖
Owner PHARMACOGENETICS