Unlock instant, AI-driven research and patent intelligence for your innovation.

Oral dissolved fenofibrate tablets

A technology of orally disintegrating tablets and fenofibrate, which is applied in the fields of pill delivery, metabolic diseases, organic active ingredients, etc., and can solve the problems of patients' annoyance and inconvenient taking of drugs

Inactive Publication Date: 2004-12-08
安徽安科恒益药业有限公司
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patients with dyslipidemia generally need long-term medication, because the current fenofibrate preparations are mostly ordinary tablets or capsules, which are not convenient to take, and patients are prone to feel tired of taking medication

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take the following raw materials,

[0031] Fenofibrate 100 servings

[0032] Microcrystalline cellulose 100 parts

[0033] Low-substituted hydroxypropyl cellulose 20 parts

[0034] Starch 30 parts

[0035] Carboxymethyl starch sodium 20 parts

[0036] Sodium saccharin 005 parts

[0037] Povidone K30 2 parts

[0038] Lemon essence amount

[0039] appropriate amount of peppermint oil

[0040] Talc powder 5 parts

[0041] Prepare granules with povidone K30 aqueous solution, after drying, granulate, spray with lemon essence and peppermint oil solution and add talcum powder, mix well, compress into tablets; make 1000 tablets in total.

[0042] The obtained tablet can rapidly expand and disintegrate and disperse in water, in 0.1 ml / L hydrochloric acid solution and in the oral cavity. The disintegration time limit is less than 3 minutes.

Embodiment 2

[0044] Take the following raw materials,

[0045] Fenofibrate 100 servings

[0046] Mannitol 200 parts

[0047] Polyethylene glycol 6000 2 parts

[0048] Sodium saccharin 0.05 part

[0049] Povidone K30 2 parts

[0050] Sodium starch glycolate 10 parts

[0051] Talc powder 5 parts

[0052] Its production method is to mix fenofibrate and mannitol, use polyethylene glycol 6000, povidone K30 and saccharin sodium aqueous solution to prepare granules, after drying, granulate, and add talcum powder and carboxymethyl starch sodium, mix Evenly, tableting; a total of 1,000 tablets were made, and the rest were the same as above.

Embodiment 3

[0054] Take the following ingredients,

[0055] Fenofibrate 100 servings

[0056] Mannitol 50 parts

[0057] Lactose 100 parts

[0058] Macrogol 6000 10 parts

[0059] Povidone K30 3 servings

[0060] Starch 50 parts

[0061] Carboxymethyl starch sodium 5 parts

[0062] Talc powder 5 parts

[0063] After passing the above-mentioned raw materials through a 100-mesh sieve, they were uniformly mixed according to the equal-volume incremental method, and directly compressed into tablets to make 1000 tablets in total. The rest is the same as above.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

An oral disintegrating table containing fenofibrate as its active component features that its excipient is prepared from more than one disintegrant (microcrystal cellulose) and more than two auxiliaries. Its advantage is high disintegrating speed in oral cavity (from several seconds to tens seconds).

Description

technical field [0001] The present invention relates to an orally disintegrating tablet containing fenofibrate active ingredient. Background technique [0002] Fenofibrate is a drug used to treat dyslipidemia. Recent clinical studies abroad believe that fenofibrate can not only reduce low-density lipoprotein, but also increase high-density lipoprotein. Fenofibrate preparations are also used in the treatment of dyslipidemia in patients with diabetes and AIDS. Fenofibrate has good pharmacokinetic characteristics, its elimination half-life is about 20 hours, and the average concentration reaches its peak after 5 hours of administration. Patients with dyslipidemia generally need long-term medication, because the current fenofibrate preparations are mostly ordinary tablets or capsules, which are not convenient to take, and patients are prone to feel tired of taking medication. Contents of the invention [0003] The present invention aims to provide a new fenofibrate dosage f...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/216A61P3/06
Inventor 张承锋丁文忠
Owner 安徽安科恒益药业有限公司