N-acyl sarcosine modified aqueous magnetic liquid and its preparation method

A technology of acyl sarcosine and magnetic liquid, which is applied in the field of water-based magnetic liquid and its preparation, can solve the problems of poor dispersion of nanoparticles, thick outer coating layer, and easy agglomeration, and achieve good biocompatibility

Inactive Publication Date: 2004-12-22
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the preparation methods of water-based magnetic liquids can be divided into three categories according to the types of stabilizers used: 1) polymers with hydrophilic groups are used as stabilizers, and the stabilizers used are mainly polysaccharides, proteins, polymers, etc. Acrylic, polyacrylamide, etc., the current disadvantages of this type of water-based magnetic liquid are thick outer coating layer and low saturation magnetization; 2) Use water-soluble small organic molecules such as amino acids, citric acid, folic acid, etc. as chelating agents and stabilizer, the existing problem of this type of water-based magnetic liquid is that the nano-particles are not well dispersed and easy to agglomerate; 3) the use of surfactants to form a double-layer adsorption mode on the surface of nano-magnetic particles to prepare water-based magnetic liquids is currently available internationally. There are reports on the preparation of water-based magnetic liquids by using fatty acids to form double-layer adsorption on the surface of nano-magnetic particles, but the effect of connecting cells, proteins or genes with this water-based magnetic liquids is not ideal.

Method used

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  • N-acyl sarcosine modified aqueous magnetic liquid and its preparation method
  • N-acyl sarcosine modified aqueous magnetic liquid and its preparation method
  • N-acyl sarcosine modified aqueous magnetic liquid and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Take 100g FeSO 4 .7H 2 O, formulated as FeSO with a mass concentration of 30% 4 solution, weighing 195gFeCl 3 .6H 2 O, formulated as FeCl with a mass concentration of 70% 3 solution, the two solutions are mixed according to the ratio of ferrous sulfate:ferric chloride (molar ratio)=1:1.5 to form an iron salt mixed solution. At the same time, add iron salt mixed solution and 450ml of ammonia water with a concentration of 25%, stir at high speed, adjust the rotation speed to 1300 rpm, and keep the reaction temperature at about 60°C for 10 minutes. To remove Cl - , SO 4 -2 and NH 4 + Etc., add 800ml distilled water in the reaction system under stirring condition after reaction finishes, continue to stir 3 minutes under stirring speed 400 revs / min, adopt magnetic seat settling to separate nano ferroferric oxide magnetic particle and supernatant liquid, carry out 3 times repeatedly Second-rate. Add a small amount of distilled water and 30ml of oleoyl sarcosine to ...

Embodiment 2

[0026] Take 100g FeSO 4 .7H 2 O, formulated as FeSO with a mass concentration of 15% 4 solution, weighing 195gFeCl 3 .6H 2 O, formulated as FeCl with a mass concentration of 60% 3 Solution, all the other steps are with embodiment 1. The saturation magnetization of magnetic liquid can reach 300 Gauss.

Embodiment 3

[0028] Take 100g FeSO 4 .7H 2 O, formulated as FeSO with a mass concentration of 20% 4 solution, weighing 195gFeCl 3 .6H 2 O, formulated as FeCl with a mass concentration of 65% 3 Solution, all the other steps are with embodiment 1. The saturation magnetization of magnetic liquid can reach 300 Gauss.

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Abstract

A N-acylsarcosine modified water-base magnetic liquid used as magnetic carrier to separate cell, protein and gene is prepared through synthesizing and washing magnetic nanoparticles, and using N-acylsarcosine as tabilizer to prepare magnetic liquid.

Description

technical field [0001] The invention relates to a water-based magnetic liquid and a preparation method thereof, in particular to an N-acyl sarcosine modified water-based magnetic liquid and a preparation method thereof. Background technique [0002] The so-called magnetic liquid refers to a stable colloidal system formed by highly dispersed nano-magnetic particles adsorbed with a stabilizer in a carrier liquid. It is mainly composed of nano magnetic particles, stabilizer and carrier liquid. At present, the preparation methods of water-based magnetic liquids can be divided into three categories according to the types of stabilizers used: 1) polymers with hydrophilic groups are used as stabilizers, and the stabilizers used are mainly polysaccharides, proteins, polymers, etc. Acrylic, polyacrylamide, etc., the current disadvantages of this type of water-based magnetic liquid are thick outer coating layer and low saturation magnetization; 2) Use water-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/00
Inventor 徐雪青沈辉许家瑞
Owner SUN YAT SEN UNIV
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