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Solid prepn. of sodium vitamin C for injection and its prepn. method

A technology for solid preparations and vitamins, which is used in pharmaceutical formulations, medical preparations containing active ingredients, and drug combinations to achieve the effects of long storage period, expanding application scope and reducing clinical large doses.

Inactive Publication Date: 2005-01-05
马立群
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is also used clinically for the treatment of vitamin C deficiency and other diseases. Its dosage form is oral solid preparation. At present, there is no vitamin C sodium solid preparation for injection at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Preparation ratio

[0034] Sodium Vitamin C 98.9%

[0035] Vitamin C 1.1%

[0036] (2) Preparation method

[0037] Under sterile conditions, weigh sterile vitamin C sodium and vitamin C according to the ratio, mix them, grind them, pass through a 40-mesh sieve, dry them under reduced pressure at 60°C, and pack them in glass bottles at 0.56 grams or 1.13 grams each. , cover, label, and pack to obtain a finished product. The specification of the finished product is that each bottle contains 0.5 g or 1.0 g of vitamin C.

Embodiment 2

[0039] (1) Preparation ratio

[0040] Sodium Vitamin C 99.99%

[0041] Vitamin C 0.01%

[0042] (2) Preparation method

[0043] Weigh vitamin C sodium and vitamin C according to the ratio, add 60°C water for injection to dissolve, add 0.1% activated carbon for injection, stir for 15 minutes, then filter, collect the filtrate, add water for injection to a certain volume, under sterile conditions Filter with a 0.22μm microporous membrane, measure the content of the filtrate, and divide it into glass bottles. After freezing into a solid at -55°C in a freeze dryer, start vacuuming, and at the same time slowly and gradually increase the temperature to 40°C to obtain a white powder. Shaped or loose lumps, sealed with rubber stoppers, capped and packaged.

Embodiment 3

[0045] (1) Preparation ratio

[0046] Sodium Vitamin C 98.0%

[0047] Vitamin C 1.898%

[0048] Sodium edetate 0.002%

[0049] Sodium metabisulfite 0.1%

[0050] (2) Preparation method

[0051] Under sterile conditions, weigh sterile sodium vitamin C, vitamin C, sodium ethylenediamine tetraacetate and sodium metabisulfite according to the ratio, mix, grind, pass through an 80-mesh sieve, and dry under reduced pressure. Put it in a glass bottle, cover it, stick a label, and pack it to get a finished product. The specification of the finished product is that each bottle contains 2.5 grams of vitamin C.

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PUM

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Abstract

A solid-state VC sodium injection for treating the diseases caused by VC difficiency is prepared from VC sodium, VC and the pharmacologically acceptable additives.

Description

technical field [0001] The invention relates to vitamin medicines, in particular to vitamin C sodium solid preparations. Background technique [0002] Vitamin C is a variety recorded in the Pharmacopoeia of the People's Republic of China in 2000 (P791). Its aliases include ascorbic acid, vitamin C, vitamin C, etc. It has a wide range of physiological functions, participates in the synthesis of collagen and tissue repair in the body, and participates in certain redox reactions in the body. and metabolic processes. Clinically, it is mainly used to prevent and treat vitamin C deficiency, and it can also be used as adjuvant therapy for infectious diseases, purpura, acute exacerbation of Keshan disease, chronic iron poisoning, cancer and other diseases. [0003] At present, vitamin C preparations clinically used for injection include vitamin C injection and aseptic subpackaged vitamin C powder injection, both of which are produced with vitamin C as raw material. There are many ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/375A61P3/02
Inventor 马立群
Owner 马立群
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