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Novel sodium houttuyfonate powder injection

A technology of new houttuyniacin sodium and powder injection, applied in the field of medicine, can solve the problems of increasing the production cost of new houttuyniacin sodium powder injection for injection, unstable storage period, unstable and easy precipitation, etc., and achieves clinical use. Safety, improved stability, improved solubility

Inactive Publication Date: 2005-01-12
肖广常 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This has brought inconvenience for the clinical use of this medicine, has also illustrated the shortcoming of this medicine simultaneously: unstable in storage period, easy to separate out
[0004] In order to solve the instability and easy-to-precipitate shortcomings of the new houttuyniatin sodium injection, someone applied for a patent for "Application of 2-hydroxypropyl β-cyclodextrin in the preparation of new houttuyniatin sodium injection", application number It is 03126536.7, and the publication number is CN1449834A. In this patent application, 2-hydroxypropyl β-cyclodextrin is used to clathrate and solubilize neohouttuyfonate sodium, although 2-hydroxypropyl β-cyclodextrin Solved the water-soluble problem of new houttuyfonate sodium, but the market price of 2-hydroxypropyl β-cyclodextrin is very high, and the dosage is large, thus greatly improving the production of new houttuyfonate sodium powder for injection cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 Neohouttuydin Sodium Powder Injection for Injection, the components are as follows, all in percent by weight:

[0019] Neohouttuydin Sodium 0.17%

[0020] Tween-80 33.27%

[0021] Mannitol 66.56%

[0022] The preparation method is as follows:

[0023] Take 10g of new houttuyonin sodium raw material, Tween-80 2000g, add 15L of water for injection at 70°C-85°C, control the temperature at 70°C-85°C when dissolving, add 4000g of mannitol to dissolve, add water for injection to 20L , stir until completely dissolved, add charcoal for needles and stir at room temperature for 30 minutes, filter and decarbonize, fine filter, and vacuum-dry the filtrate to obtain new houttuyfonate sodium sterile powder. Then carry out aseptic sub-package according to 20ml of each to obtain the new houttuyfonate sodium powder for injection.

Embodiment 2

[0024] Example 2 Neohouttuydin Sodium Powder Injection for Injection, the components are as follows, all in percent by weight:

[0025] Neohouttuydin Sodium 2.17%

[0026] Tween-80 21.73%

[0027] Lactose 76.10%

[0028] The preparation method is as follows:

[0029] Take 20g of new houttuyfonate sodium raw materials, Tween-80 200g, add 3.5L of water for injection at 70°C-85°C, control the temperature at 70°C-85°C during dissolution, add 700g of mannitol to dissolve, add water for injection to 4L, stir until completely dissolved, add charcoal for needles, stir at room temperature, filter to remove charcoal, fine filter, and the filtrate is spray-dried to obtain new Houttuyfonate Sodium sterile powder. Then carry out aseptic sub-package according to each 4ml to obtain new houttuyfonate sodium powder for injection.

Embodiment 3

[0030] Example 3 Neohouttuydin Sodium Powder Injection for Injection, the components are as follows, all in percent by weight:

[0031] Neohouttuydin Sodium 4.76%

[0032] Polyoxyethylene hydrogenated castor oil 95.24%

[0033] The preparation method is as follows:

[0034] Take 4g of new houttuyniatin sodium raw material, 80g of polyoxyethylene hydrogenated castor oil, add 0.8L of water for injection at 70°C-85°C, control the temperature at 70°C-85°C during dissolution, add water for injection to 1L, and stir until Dissolve completely, add charcoal for needles, stir at room temperature, decarbonize by filtration, and fine filter. The filtrate is divided into 1ml per capsule, and freeze-dried to obtain Neohouttuyfonate Sodium Powder for Injection.

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PUM

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Abstract

A powder injection of sodium neohouttuyfonate for treating pelvic inflammation, adnexitis, chronic cervicitis, upper respiratory tract infection, etc contains sodium neohouttuyfonate, solubilizer,and excipient.

Description

(1) Technical field [0001] The invention relates to a new houttuyfonate sodium powder injection for injection, which belongs to the technical field of medicine. (2) Background technology [0002] Neohouttuydin Sodium is a synthetic product with the chemical name sodium laurylacetaldehyde bisulfite. This product is easily soluble in hot water, slightly soluble in water and ethanol, almost insoluble in chloroform and benzene, and almost insoluble in hydrogen Sodium oxide is easily soluble in the test solution, but it decomposes at the same time (National Drug Standard Chemical Drug Local Standard Rising National Standard Volume 5 P273). [0003] The usage and dosage of the instructions of the new houttuybein sodium injection in the national drug standard (the local standard of chemical drugs has risen, the fourth volume of the national standard P323) describes the usage and dosage of the new houttuynin sodium injection can be used for intramuscular injection or intravenous inf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/255A61P11/00A61P15/00A61P29/00
Inventor 肖广常张颖
Owner 肖广常
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