Nitrol ointment, preparation method and application thereof

Abstract

The invention provides a nitrol ointment, preparation method and application thereof, wherein the ointment comprises nitroglycerin, emulsifying agent, deflocculating agent and water, it can be used for treating male erection dysfunction and female sex hypofunction. The advantages of the invention include increased medicament stability, strong safety, simple process for manufacturing, and low cost of manufacture.

Description

1. Technical field [0001] The invention relates to a nitroglycerin ointment for external use, in particular to a nitroglycerin ointment for external use for treating sexual dysfunction, promoting capillary expansion, especially for treating erectile dysfunction, and a preparation method and application thereof. 2. Background technology [0002] Nitroglycerin is an old drug against angina pectoris. It has been clinically used for more than 100 years. It has a quick onset and a short duration of action. Nitrates can bind to nitrate receptors in smooth muscle cells and be reduced by the sulfhydryl groups of nitrate receptors to form NO or -SNO (nitrososulfhydryl). In addition, the released NO can also inhibit platelet aggregation and adhesion, which is beneficial to the treatment of coronary heart disease. [0003] With the deepening understanding of the mechanism of NO in the circulation, immunity and nervous system, the application of NO and NO-related drug therapy has becom...

AI Technical Summary

Problems solved by technology

[0011] The invention patent "water-based topical cream containing nitroglycerin and its preparation method and application" (ZL patent No. 96192273.7) applied by American International Medical Innovation Co., Ltd. in China, the topical cream is composed of 0.1-3% by weight of nitroglycerin , 5-24% by weight of penetration enhancer, 60-90% by weight of water, 0.5-3% by weight of thickener and 0.4-2% by weight of emulsifier. Our test results show that 60%- The water content of 90% is enough to hydrolyze the nitroglycerin, because the nitroglycerin is generally stored in absolute ethanol, so the cream for external use is unstable. In addition, the preparation method of the cream is relatively complicated, and more auxiliary materials are added. The production cost is high, and at the same time, similar drugs in the prior art also have problems such as insufficient stability and weak safety