Application of 20(R)-ginsenoside-Rg3 in the preparing process of medicine for treating or preventing cardiovascular and cerebrovascular disease

A technology for cardiovascular and cerebrovascular diseases and ginsenosides, applied in cardiovascular system diseases, drug delivery, drug combination, etc.

Inactive Publication Date: 2005-01-26
SHANDONG GREENERY NATURAL MEDICINE RES & DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] According to reports, Rg 3 It has anti-tumor, anti-angiogenesis, anti-inflammation and other effects, but about 20(R)-ginsenoside-Rg 3 There is no report on the effect of preventing or treating cardiovascular and cerebrovascular diseases; in view of this, the inventor has surprisingly found that 20 (R)-ginsenoside-Rg 3 It has the medicinal purpose of preventing or treating cardiovascular and cerebrovascular diseases

Method used

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  • Application of 20(R)-ginsenoside-Rg3 in the preparing process of medicine for treating or preventing cardiovascular and cerebrovascular disease

Examples

Experimental program
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preparation Embodiment 1

[0016] Preparation Example 1: Preparation Example of Preparation for Injection

[0017] Weigh 1.00g 20(R)-ginsenoside-Rg 3 , add 20ml of n-butanol and 30ml of propylene glycol to completely dissolve the saponins, add 0.15g of tetracaine hydrochloride and 0.02g of citric acid into 40ml of water for injection to dissolve completely, and add the above aqueous solution to the drug solution, mix Uniform; use borax and boric acid to adjust the pH value to 5.5±1.0; add 0.1% activated carbon for needles and keep warm at 85°C for 30 minutes, G 3 Filtrate through a vertically fused glass funnel, and filter through a 0.22um microporous membrane; the filtrate is divided into 7ml vials, each with a volume of 2ml (the divided injection can be directly pressed into a stopper, pressed into an aluminum cap to form an injection; or freeze-dried Machine freeze-drying to make freeze-dried powder.).

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Abstract

The invention relates to the application of 20(R)-ginsenoside-Rg3 in the preparing process of medicine for treating or preventing hypertension, in preparing medicine for treating or preventing myocardial ischemia, and in preparing medicament for prevention or treatment of heart failure.

Description

technical field [0001] The present invention relates to 20(R)-ginsenoside-Rg 3 Application in the preparation of medicines for treating or preventing cardiovascular and cerebrovascular diseases. Background technique [0002] With the acceleration of population aging process and changes in lifestyle, cardiovascular and cerebrovascular diseases have become a global health problem. The mortality rates of coronary heart disease and stroke rank first and third in the world respectively. Hypertension has always been considered is a major risk factor for stroke. The development of new and effective drugs for the prevention and treatment of cardiovascular and cerebrovascular diseases is urgent. [0003] 20(R)-Ginsenoside-Rg 3 It is a tetracyclic triterpenoid panaxadiol saponin monomer isolated from ginseng. [0004] [0005] 20(R)-Ginsenoside-Rg 3 Structural formula (R: -glu-o-glu; R 1 :-CH 3 ; 2 :-OH) [0006] According to reports, Rg 3 It has anti-tumor, anti-angi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/704A61P9/10
Inventor 田京伟傅风华蒋王林王超云
Owner SHANDONG GREENERY NATURAL MEDICINE RES & DEV
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