External used gel of Jiatishacin and its preparation

The technology of a gel for external use and gatifloxacin is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, local antibacterial agents, etc. It can solve the problems that there are no research reports on the gel for external use, and achieve the goal of benefiting the drug. release, reduce side effects, and improve medication compliance

Inactive Publication Date: 2005-02-23
李东
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The fourth-generation quinolone antibacterial drugs, such as gatifloxacin, have not yet been developed and applied in clinical formulations for external use
There are 2nd and 3rd generation quinolones such as ciprofloxacin, ofloxacin, levofloxacin, norfloxacin and spafloxacin that have been developed and applied at home and abroad, but there is no 4th generation gel at present. Research Report on GFLX External Gel

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment one. Gatifloxacin gel for external use is made of the following medicines in percentage by weight:

[0027] Gatifloxacin 0.3%

[0028] Propylene Glycol 10%

[0029] Glycerin 10%

[0030] Carbomer 940 1%

[0031] Triethanolamine 1.5%

[0032] Distilled or purified water add up to 100%

[0033] The situation of utilizing the medicine of the present invention to carry out clinical trials is as follows:

[0034] (1) Cases were selected from the obstetrics and gynecology outpatient clinic, who were diagnosed as bacterial vaginosis (bacterial vaginosis) according to the diagnostic criteria (Edited by Le Jie. Obstetrics and Gynecology. 5th Edition. Beijing: People's Health Publishing House, 2002, 287) 88 cases, with an average age of 29.8 years.

[0035] (2) Administration method Before the patient goes to bed every night, inject about 5g of gel into the deep vagina, once a day, 7 days as a course of treatment.

[0036] (3) Criteria for judging curative effe...

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PUM

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Abstract

An exterior-applied gel of Jiatishaxing is prepared through adding carbomer to glycerine, grinding, adding distilled water, grinding, adding the aqueous solution oftriethanolamine to obtain gel matrix, dissolving Jiatishaxing in distilled water, adding propanediol, stirring, slowly adding it to said gel matrix, adding distilled water and grinding.

Description

technical field [0001] The invention relates to an external drug for treating human skin and mucous membrane sensitive microbial infection and a preparation method thereof, in particular to a slow-release external gel for treating infections in dermatology, general surgery, urology and gynecology and a preparation method thereof. Background technique [0002] So far, the antibacterial drugs for external use for the treatment of human skin and mucous membrane microbial infectious diseases have few varieties and aging products. For example: "Chinese Pharmacopoeia" 2000 edition contains 14 antibacterial drugs for external use, such as erythromycin ointment, enoxacin ointment, compound clotrimazole ointment, compound neomycin ointment, aureomycin hydrochloride ointment, norfloxacin Ointment, silver sulfadiazine ointment, silver sulfadiazine cream, zinc sulfadiazine ointment, sulfadiazine ointment, etc. At present, the preferred topical quinolone antiba...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/496A61P13/00A61P15/00A61P17/00A61P31/02
Inventor 李东陈丽娜聂中越
Owner 李东
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