6-O-acyl ketolide derivatives of erythromycine useful as antibacterials

Abstract

6-O-Acyl ketolide antibacterials of the formula (I), wherein R1, R2, R3, R4, W, X, X', Y, and Y' are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.

Description

[0001] Cross References to Related Applications

[0002] This application claims the benefit under 35 U.S.C. § 119(e) of provisional patent serial nos. 60 / 392,513, filed June 28, 2002, and 60 / 338,566, filed December 5, 2001, both provisional applications Both are incorporated herein by reference. field of invention

[0003] The field of the invention relates to macrolide compounds having antibacterial activity, to pharmaceutical compositions containing such compounds, and to methods of using such compounds to treat bacterial infections. Background of the invention

[0004] Erythromycin is well known as an antibacterial agent widely used in the treatment and prevention of bacterial infections caused by Gram-positive and Gram-negative bacteria. However, due to the low stability of erythromycin in an acidic environment, negative reactions such as poor and unstable oral absorption often occur. As with other types of antimicrobials,...

Images