Sustained release compound capsules and its preparation method

A technology for sustained-release capsules and compound recipes, applied in the field of compound sustained-release capsules and their preparation, can solve the problems of non-disclosure and the like, and achieve the effect of improving bioavailability

Active Publication Date: 2005-03-16
HAINAN PULIN PHARMA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The prior art has not disclosed that once-a-day administration of the present invention will have sustained-release pseudoephedrine pellets and tablets containing desloratadine are jointly filled in the same capsule to form a compound preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0030] Embodiment: This embodiment prepares 10000 compound sustained-release capsules

[0031] 1, the preparation of desloratadine tablet:

[0032] Plain tablet prescription: desloratadine 25g starch 270g

[0033] Dicalcium Phosphate 90g Povidone 10g

[0034] Carboxymethyl Starch Sodium 90g Micropowder Silica Gel 5g

[0035] Magnesium Stearate 5g

[0036] a. Pass desloratadine and starch through a 120-mesh sieve, and calcium hydrogen phosphate through a 100-mesh sieve for subsequent use;

[0037] B, prepare 10% povidone (70% alcohol solution) solution and take desloratadine, starch calcium hydrogen phosphate and 2 / 3 amount of carboxymethyl starch sodium and mix evenly;

[0038] c, with 10% povidone K30 alcohol solution, the mixed material is made into a uniform soft material, and granulated through a 30 mesh sieve;

[0039] d. Dry at 55°C, sieve through a 30-mesh sieve, add the remaining sodium carboxymethyl starch, micronized silica gel, and...

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PUM

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Abstract

The invention discloses a sustained release compound capsules and its preparation method, wherein each capsule comprises a desloratadine tablet and a plurality of pseudo ephedrine slow release particles, the active components include desloratadine 2.5mg-5mg, pseudo ephedrine 120mg-240mg. The compound slow release capsule can increase the biological availability and compliableness for the patients.

Description

technical field [0001] The invention relates to a dosage form of medicine, in particular to a compound sustained-release capsule and a preparation method thereof. Background technique [0002] Current treatment of patients presenting with signs and symptoms associated with allergic and / or inflammatory conditions (e.g. the common cold) and with allergic and / or inflammatory conditions of the skin or upper and lower Patients with allergic rhinitis and nasal congestion upper respiratory diseases, signs and symptoms related to allergic rhinitis and nasal congestion, are generally treated with combination therapy of desloratadine and pseudoephedrine or its pharmacologically active salt refers to pseudoephedrine sulfate. However, the current dosage form needs to be taken several times a day, resulting in poor compliance of patients and easily causing missed doses. Due to the disparity between the half-life of pseudoephedrine and the half-life of deslorata...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K31/4545A61P11/02
Inventor 范敏华
Owner HAINAN PULIN PHARMA
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