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Process for preparing N-acetyl-L-tyrosine

A technology of acetyltyrosine and tyrosine, which is applied in the field of amino acid preparation, can solve the problems of large amount of solvent, low purity of crude products, environmental pollution and the like, and achieves the effects of easy disposal of three wastes, short technological process and high purity

Active Publication Date: 2005-03-16
WUHAN GRAND HOYO
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Problems solved by technology

The acylation process of this method will produce sodium acetate, the purity of the crude product is low, the amount of solvent used is large, there is a problem of solvent recovery, and the investment is large; if the solvent is not recovered, it will cause environmental pollution

Method used

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  • Process for preparing N-acetyl-L-tyrosine

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Embodiment Construction

[0008] Since L-Tyr has α-NH 2 and aromatic nucleus -OH two acylating groups, the former is weaker in electronegativity than the latter, easier to acetylate, and the N-Ac bond formed is more stable than the O-Ac bond. During the acylation reaction, in order to acylate the aromatic nucleus -OH group as little as possible, the formed O-Ac bond can be hydrolyzed in the subsequent process. For this reason, we prefer to use a medium-strength acetylating agent-acetic anhydride as the acylating agent.

[0009] The L-tyrosine and acetic anhydride with a weight ratio of 1:3~5 are acylated in an aqueous medium, the reaction temperature is controlled between 50-80°C, and the reaction time is controlled between 45-75 minutes. After 60 minutes, recover the solvent, and dry it by centrifugation, that is, the reaction solution after the acylation, vacuum the acid, and control the vacuum degree and temperature. The vacuum degree is 80-100mmhg, and the temperature is 75-80°C. O-Ac generated d...

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Abstract

The invention discloses a process for preparing N-acetyl-L-tyrosine which comprises the steps of, dissolving L-tyrosine into aqueous medium, conducting acetylization 45-75 minutes at 50-80 deg. C by using acetic anhydride as acylating agent, obtaining crude product through concentration, dissolving dried crude product into 75-80 deg C hot water, decolorizing, filtering, concentrating, crystallizing and drying.

Description

technical field [0001] The invention belongs to the preparation method of amino acid, in particular to the preparation method of N-acetyl-L-tyrosine. Background technique [0002] The amino acid raw materials used in the production of amino acid infusion in my country are mainly 20 basic varieties, and the infusion containing only 17 kinds of amino acids stipulates that N-acetyl-L-tyrosine is used instead of tyrosine. Only this item is expected to use N - Acetyl-L-tyrosine 8 tons more. Because the solubility of tyrosine is too small, which is not conducive to its absorption and utilization, foreign infusion production has shown the trend of using N-acetyl-L-tyrosine instead of tyrosine. The amount of tyrosine used in the production of infusion in my country is about 100 tons, and it can be seen that it will be gradually replaced by N-acetyl-L-tyrosine. At present, there is no domestic manufacturer producing N-acetyl-L-tyrosine. The method of producing N-acetyl-L-tyrosine ab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C231/10C07C233/47
Inventor 刘爱福
Owner WUHAN GRAND HOYO