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Medicinal composition containing Aerican ginseng and tuber of dwarf lily turf effective part and its preparing method

A technology of effective parts and American ginseng, which is applied in the directions of medical preparations containing active ingredients, drug combinations, drug delivery, etc., can solve the problems of elaboration of the extraction process, inability to replicate in reality, complicated and complicated operations, etc., and achieve good pharmacological effects. Effect

Inactive Publication Date: 2005-05-18
张平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The patent "Application of Shenmai Injection in the Production of Anticancer Drugs" (Application No. 94107143) only briefly introduces the extraction of ginseng and Ophiopogon japonicus with ethanol, without elaborating on the extraction process; the patent "A freeze-dried powder of Shenmai injection "(Application No. 94113809) introduced the simple ethanol extraction of ginseng and Ophiopogon japonicus, and the extract was processed by preparation and then freeze-dried to prepare freeze-dried powder. (Application No. 98112180) only briefly introduced the method of extracting ginseng and Radix Ophiopogon japonicus respectively with ethanol, and this method also can be consulted and obtains in periodical literature; ) used a resin chromatography column for purification, did not fully explain what type of resin column to use, could not be replicated in reality, and had to perform two resin columns, the operation was cumbersome and complicated; consulting patents and literature, no American ginseng and barley Compatibility prepared into preparations in winter

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Hemolysis experiment of each group of preparations of the present invention

[0055] Experimental drug: Shenmai injection (Shijiazhuang Shenwei Pharmaceutical Co., Ltd.);

[0056] The injection preparation of the present invention (provided by the laboratory of Guangdong Tianzhijiao Pharmaceutical Development Co., Ltd.)

[0057] Normal saline (provided by the laboratory of Guangdong Tianzhijiao Pharmaceutical Development Co., Ltd.)

[0058] Experimental method: Take fibrin-free rabbit whole blood, add physiological saline, shake well, centrifuge, pour out the supernatant, wash repeatedly until it does not turn red, measure the red blood cells, and dilute with physiological saline to a 2% suspension. Take 2ml each of Shenmai injection and each group of preparations of the present invention (treat each group of preparations of the present invention to a solution with the same concentration as commercial Shenmai injection), add 2.5ml of 2% red blood cell suspension, and add ph...

Embodiment 2

[0071] Hemolysis of ethanol extract of American ginseng

[0072] Take different American ginseng alcohol extracts (with ginsengdiol saponin Rb 1 Recorded as 10%, 15%, 25%, 30%, 31%, 35%) The above hemolysis experiment was performed, and the results are shown in Table 3.

[0073] Table 3 Hemolysis of different alcohol extracts of American ginseng

[0074] Group 3 hours 4 hours 6 hours

[0075] American ginseng alcohol extract (with ginsenoside Rb 1 Recorded as 10% group)---

[0076] American ginseng alcohol extract (with ginsenoside Rb 1 Recorded as 15% group)---

[0077] American ginseng alcohol extract (with ginsenoside Rb 1 Recorded as 25% group---

[0078] American ginseng alcohol extract (with ginsenoside Rb 1 Recorded as 30% group)---

[0079] American ginseng alcohol extract (with ginsenoside Rb 1 Recorded as 31% group)-+- +

[0080] American ginseng alcohol extract (with ginsenoside Rb 1 Recorded as 35% group) +- + +

[0081] Note: + m...

Embodiment 3

[0084] Protective effect on acute myocardial ischemia in rats

[0085] Experimental drug: Shenmai injection (Shijiazhuang Shenwei Pharmaceutical Co., Ltd.);

[0086] The injection preparation of the present invention (provided by the laboratory of Guangdong Tianzhijiao Pharmaceutical Development Co., Ltd.)

[0087] Normal saline (provided by the laboratory of Guangdong Tianzhijiao Pharmaceutical Development Co., Ltd.

[0088] Experimental animals: 80 Wister rats, male, weighing (300±20) g, were divided into 5 groups, each with 10 rats.

[0089] Experimental method: Ligation of the left anterior descending coronary artery in rats caused an acute myocardial ischemia model. Each group was given tail vein administration (2.5g / kg administration), 20% urethane (1g / kg, ip) anesthesia, the common carotid artery was separated, and tracheal intubation was performed, and the animal ventilator was connected. Open the chest in the fourth intercostal space on the left, cut the open heart bag, s...

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PUM

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Abstract

The present invention discloses one medicinal composition containing the effective parts of American ginseng and ophiopogon root and its preparation process. The present invention features that extracted and purified effective parts of American ginseng and ophiopogon root and medicinal supplementary material are prepared into the injection preparation, and that the medicine composition has excellent pharmacological effect and limited content of panoxadiol saponin with bad hemolytic reaction, and thus safe clinical application. Pharmacological experiment shows that the medicine composition preparation has even high pharmacological effect and safety compared with similar marketed product.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and specifically relates to a pharmaceutical composition containing effective parts of American ginseng and Ophiopogon japonicus and a preparation method thereof. Background technique [0002] Ginseng is a plant of the Araliaceae family, which has the functions of invigorating vitality, rejuvenating the veins, strengthening the spleen and lungs, and promoting body fluids and soothing the nerves. Ginseng mainly contains ginsenosides, the content of which is about 4%, and is divided into oleanolic acid according to different aglycones. Ginseng, ginseng diols, ginseng triols, ginseng diol saponins and ginseng triol saponins with good pharmacological activity; American ginseng is also called American ginseng, American ginseng, American ginseng, etc. The origin is in the United States and Canada, but The earliest clinical application and the largest amount in China. The Americ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/14A61P9/00A61P9/02A61P9/10A61P11/00A61P31/12A61P35/00
Inventor 张平
Owner 张平
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