Small interference ribonucleic acid molecule for epidermal growth facor gene and its use

A technology of epidermal growth factor and ribonucleic acid, which is applied in the field of preparing drugs that can effectively kill tumor cells, and can solve problems such as lack of treatment methods
CN1616476AInactive Publication Date: 2005-05-18ZHEJIANG UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2005-05-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides one small interference ribonucleic acid (SiRNA) as the active component for antitumor medicine to kill tumor cell and for epidermal growth factor Cripto gene mRNA. Its nucleotide sequence has one negative chain and one nucleotide mutant without homology to known human gene. The SiRNA can inhibit the expression of human colon cancer LS-174T cell Cripto gene effectively via intracellular RISC, and is favorable to treating colon cancer and other malignant tumor with up expressing Cripto gene. Therefore, the SiRNA may be used in medicine for treating malignant tumor and relevant disease with up expressing Cripto gene.
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Description

technical field

[0001] The invention relates to the field of nucleic acid technology, in particular to a small interfering ribonucleic acid molecule (SiRNA) directed at the mRNA of the epidermal growth factor (Cripto) gene and its application in the preparation of drugs for effectively killing tumor cells. Background technique

[0002] Malignant tumor is a major disease that endangers human life and health, but so far there is still no effective treatment for it. Scientists have long been trying to develop new drugs that can effectively treat malignant tumors.

[0003] According to the statistics of the World Health Organization, there are about 10 million new malignant tumor patients in the world every year, and 6 to 7 million people die from tumors. In my country, there are about 2 million new cases each year, and about 1.4 million deaths (calculated according to a population of 1.3 billion). This trend will continue as the effects of aging populations, smoking, urbaniza...

Claims

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