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Novel nimodipine composition

A composition, nimodide technology, applied in the new composition field, can solve problems such as unfavorable stability, safety and preparation

Active Publication Date: 2005-07-06
REYOUNG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The formulation is detrimental to stability, safety and preparation due to the substances it contains

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0177] Nimodipine freeze-dried powder injection

[0178] Nimodipine 20g

[0179] Macrogol 400 200g

[0180] Tween-80 200g

[0181] Hydroxypropyl-β-cyclodextrin 500g

[0182] Appropriate amount of water for injection

[0183] ① Add the prescribed amount of nimodipine into the mixture of polyethylene glycol 400 and Tween-80, heat and stir to dissolve;

[0184] ② Add hydroxypropyl-β-cyclodextrin to water, heat and stir to dissolve, add the above solution while stirring, continue stirring, to room temperature;

[0185] ③ Add appropriate amount of activated carbon, keep warm at 60°C for 20 minutes and stir.

[0186] ④ Filtration, fine filtration, determination of content, canning into 1000 bottles, freeze-drying, to get final product.

Embodiment 2

[0188] Nimodipine freeze-dried powder injection

[0189] Nimodipine 10g

[0190] Macrogol 400 100g

[0191] Tween-80 100g

[0192] Hydroxypropyl-β-cyclodextrin 250g

[0193] Appropriate amount of water for injection

[0194] ① Add the prescribed amount of nimodipine into the mixture of polyethylene glycol 400 and Tween-80, heat and stir to dissolve;

[0195] ② Add hydroxypropyl-β-cyclodextrin to water, heat and stir to dissolve, add the above solution while stirring, continue stirring, to room temperature;

[0196] ③ Add an appropriate amount of activated carbon, keep warm at 60°C for 20 minutes and stir.

[0197] ④ Filtration, fine filtration, determination of content, canning into 1000 bottles, freeze-drying, to get final product.

Embodiment 3

[0199] Nimodipine freeze-dried powder injection

[0200] Nimodipine 5g

[0201] Macrogol 400 200g

[0202] Tween-80 200g

[0203] Hydroxypropyl-β-cyclodextrin 500g

[0204] Appropriate amount of water for injection

[0205] ① Add the prescribed amount of nimodipine into the mixture of polyethylene glycol 400 and Tween-80, heat and stir to dissolve;

[0206] ② Add hydroxypropyl-β-cyclodextrin to water, heat and stir to dissolve, add the above solution while stirring, continue stirring, to room temperature;

[0207] ③ Add appropriate amount of activated carbon, keep warm at 60°C for 20 minutes and stir.

[0208] ④ Filtration, fine filtration, determination of content, canning into 1000 bottles, freeze-drying, to get final product.

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Abstract

The invention relates to a novel nimodipine composition, in particular the freeze-drying pharmaceutical composition for injection, wherein the composition Nimodipine, polyethylene glycol 400, Twain-80, Hydroxypropyl-beta-cyclodextrin, and water for injection.

Description

Technical field: [0001] The invention relates to a new composition of antihypertensive drug nimodipine, in particular to a freeze-dried drug injection composition for injection. Background technique: [0002] Nimodipine is a dihydropyridine calcium channel antagonist, which is fat-soluble, easily passes through the blood-brain barrier, and can reach a higher concentration in the brain. In the past 20 years, nimodipine has been affirmed and applied clinically in expanding cerebral blood vessels and improving cerebral blood supply. It is mainly used to prevent and treat acute ischemic cerebrovascular diseases. It also has good effects on migraine, angina pectoris, myocardial infarction and inner ear diseases. efficacy. [0003] Nimodipine has been proved by animal experiments that it mainly blocks the calcium channel of the cell membrane in the central nervous system, effectively regulates the level of intracellular calcium, and maintains normal physiological functions. Trea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/4422A61P9/12
Inventor 赵玉山任正伟李广王子伟段祥永
Owner REYOUNG PHARMA
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