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Enteric coated orally disintegrating tablet of aspirin

The technology of oral disintegrating tablet and aspirin is applied in the field of aspirin enteric-coated oral disintegrating tablet and its preparation field, and achieves the effects of timely treatment, no irritation and good taste.

Inactive Publication Date: 2005-07-06
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Reduce the irritation of the drug to the stomach and the instability of aspirin in the stomach

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] The aspirin orally disintegrating tablet of small doses of aspirin was prepared by fluidized bed coating method, after the mixed enteric coating materials acrylic resin II and acrylic resin III were mixed, and directly compressed into tablets. The specific method is as follows:

[0050] 1. Preparation of Microcapsules

[0051] Dissolve polymeric enteric coating material acrylic resin II 80g and acrylic resin III 100g in 3000g 95% ethanol, control the air inlet temperature through a fluidized bed to be 35°C (rising to 39°C later) and the spray pressure is 0.6Mpa, spray The material speed is 0.04L / min. The above solution is slowly sprayed on the surface of the micronized aspirin (1500g) drug to wrap the drug. Preparation of drug-containing microcapsules.

[0052] 2. Compression: The prepared aspirin microcapsules are mixed with other auxiliary materials and directly compressed into tablets. The prescription for 1000 tablets is as follows:

[0053] Aspir...

Embodiment 2

[0066] Small-dose aspirin enteric-coated orally disintegrating tablets were prepared by spray drying method. The specific method is as follows:

[0067] 1. Preparation of Microcapsules

[0068] Dissolve 150 g of polymeric enteric coating material cellulose acetate phthalate (CAP) in 2000 g of 95% ethanol, disperse the micronized drug aspirin (1500 g) in the above-mentioned solution containing the polymer material, and disperse evenly . Start the spray dryer, spray the liquid medicine, steam volume (0.6Mpa) 25kg / h, compressed air (0.6Mpa) 0.4m 3 / min. Preparation of drug-containing microcapsules.

[0069] 2. Tablet compression The prepared aspirin microcapsules were mixed with other excipients and directly compressed into tablets to obtain 1000 aspirin enteric-coated orally disintegrating tablets.

[0070] Enteric-coated aspirin microcapsules 55g

[0071] Mannitol 62g

[0072] Microcrystalline Cellulose 48g

[0073] Cross-linked polyvinyl...

Embodiment 3

[0081] The aspirin orally disintegrating tablet was prepared by the fluidized bed coating method, after the aspirin was wrapped in the acrylic resin of the enteric coating material, and then directly compressed into tablets. The specific method is as follows:

[0082] 1. Preparation of Microcapsules

[0083] Dissolve 150 g of polymeric enteric coating material acrylic resin II in 2895 g of 95% ethanol, control the inlet temperature to 38° C., the spray pressure to 0.5 Mpa, and the spray speed to 0.05 L / min through a fluidized bed.

[0084] The above solution is slowly sprayed on the surface of the micronized aspirin (1500g) drug to wrap the drug. Preparation of drug-containing microcapsules.

[0085] 2. Compression: The prepared aspirin microcapsules are mixed with other auxiliary materials and directly compressed into tablets. The prescription is as follows:

[0086] Enteric-coated aspirin microcapsules 55g

[0087] Mannitol 60g

[0088] Microcry...

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Abstract

The invention relates to an eEnteric coated orally disintegrating tablet of aspirin wherein the orally disintegrating tablet comprises physiological effective dose of enteric-coated aspirin and pharmaceutically acceptable carrying agents suitable for preparing orally disintegrating tablet, which comprises macromolecular material, bulking agent, crumbling agent, effervescent agent, lubricating agent, flavoring agent, and other pharmaceutically acceptable carrying agents suitable for preparing orally disintegrating tablet.

Description

Technical field: [0001] The invention relates to the field of medicine, in particular to aspirin enteric-coated orally disintegrating tablets and a preparation method thereof. When the patient takes the medicine, the medicine is taken without water or with a small amount of water, without chewing, and disintegrates in the oral cavity within 5 to 60 seconds, and the medicine enters the stomach to take effect by virtue of swallowing power. Background technique: [0002] Orally disintegrating tablets are a new form of pharmaceutical preparations, and the English name is "Orally disintegrating tables". The US FDA has approved this dosage form for marketing on the grounds that it is convenient for certain groups of people to use it, such as the elderly, children, patients with difficulty swallowing or patients in special circumstances. [0003] Definition of orally disintegrating tablet: A tablet that disintegrates or dissolves in the oral cavity without the need for water. Tec...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/616A61P9/00A61P29/00
Inventor 蔡金巧刘洪林
Owner FUKANGREN BIO PHARMA
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