Preparation and use of mannan peptide oral granule

A mannan peptide and granule technology, applied in the field of oral granule medicine, can solve the problems of poor taste, low fermentation unit, inconvenience for children to take, etc.

Inactive Publication Date: 2005-07-06
赵恒
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The original technology has long fermentation period, low fermentation unit and high production cost
Injection patients suffer a lot, capsules, oral liquids and tablets give poor taste after taking it, and it is inconvenient for children to take it

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] Mannan peptide granules with a specification of 5 mg / bag were prepared, and each bag weighed 5 grams.

[0099] Process method: first crush and sieve the mannan peptide powder and sucrose for later use.

[0100] Take 1 gram of crushed and filtered mannan peptide, 800 grams of sucrose, and 200 grams of soluble starch, add an appropriate amount of ethanol solution of 0.05 grams of tartrazine dissolved on the mixer, mix for 40-100 minutes to make a soft material, and move to granulation Pass through a 14-mesh sieve on the machine, granulate and then move to the drying room (machine) for drying. The drying temperature is 55-65°C to make mannan peptide granules. Dissolve the food flavor in an appropriate amount of ethanol and spray it into the granules evenly. and airtight for 1-2 hours, and the granules are sized again. The sum of the particle size that cannot pass through the No. 1 sieve and the No. 5 sieve cannot exceed 15%. Finally, uniform granules are obtained, and they...

Embodiment 2

[0102] Mannan peptide granules with a specification of 10 mg / bag were prepared, and each bag weighed 5 grams.

[0103] Process method: first crush and sieve the mannan peptide powder and sucrose for later use.

[0104] Put 2 grams of the weighed mannan peptide, 800 grams of sucrose, and 200 grams of soluble starch into the boiling granulator, and add an appropriate amount of ethanol solution after dissolving 0.05 grams of tartrazine as a binder, and the drying temperature is 55-65 ° C , dried for 40-100 minutes to make mannan peptide granules. Dissolve the food flavor in an appropriate amount of ethanol, spray evenly into the granules, and seal them for 1-2 hours. The granules are then sized. The sum of the sieve and the No. 5 sieve can not exceed 15%, and finally uniform particles are obtained, which are packed and made into 200 bags.

Embodiment 3

[0105] Example 3: Mannan peptide granules with a specification of 0.25 mg / bag were prepared, and each bag weighed 5 grams.

[0106] Process method: first crush and sieve the mannan peptide powder and sucrose for later use.

[0107]Take 0.5g of crushed and filtered mannan peptide, 800g of sucrose, 200g of soluble starch, add an appropriate amount of ethanol solution of 0.05g of tartrazine dissolved on the mixer, mix for 40-100 minutes to make a soft material, and move to granulation Pass through a 14-mesh sieve on the machine for granulation, and then move to the drying room (machine) for drying. The drying temperature is 55-65°C to make mannan peptide granules. Dissolve the food flavor in an appropriate amount of ethanol and spray it evenly. In the granules, and sealed for 1-2 hours, the granules are sized again, and the sum of the particle size that cannot pass through the No. 1 sieve and the No. 5 sieve cannot exceed 15%. Finally, uniform granules are obtained, and they are ...

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PUM

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Abstract

The invention relates to the preparation process of oral administered powder of mannon peptide characterized in that the alpha streptococcus hemolyticus bacterial is carried to outer space by go and back type deep space vehicle, the heredity mutation of alpha streptococcus hemolyticus bacterial occurs under the special condition of outer space, bacterial with positive mutation and stable heredity are optimized after returning to the earth. Said bacterial has been preserved by China General Microbiological Culture Collection Center with serial number of CGMCCNo.1082. Said bacterial is treated as a production bacterial, and go through the process of bacterial preparation, first stage fermentation, second stage fermentation, purification and mixture with the dry powder of carrier to get oral powder. Said mannon peptide oral powder can be applied for the treatment of chronic gastritis, peptic ulcer and ulcerative colitis.

Description

technical field [0001] The invention relates to an oral granule medicine, in particular to the preparation and application of a mannan peptide oral granule. Background technique [0002] The drug mannan peptide produced by the common α-hemolytic Streptococcus No. 33 was listed in the domestic market as early as 1986. Its dosage forms include injection, oral liquid, tablet and capsule. And it is only used as an immune enhancer. The pharmacological effect is to activate lymphocytes, promote the differentiation and proliferation of thymus lymphocytes, promote the body's anti-tumor immune function, activate macrophages, increase leukocyte production, promote complement production, and promote interleukin -1 generation, improve bone marrow hematopoietic function. The original technology has long fermentation period, low fermentation unit and high production cost. Injection patients suffer a lot, capsules, oral liquids and tablets have poor mouthfeel afte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K38/16A61P1/00A61P1/04A61P1/14A61P11/04A61P11/06A61P25/00A61P25/16A61P25/20C12N1/20C12P19/04
Inventor 赵恒刘恒
Owner 赵恒
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