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Chinese medicine composition for treating menstrual period syndrome

A premenstrual syndrome and composition technology, which is applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of no control and statistical processing, affecting the objective evaluation of clinical efficacy, and lack of diagnostic indicators

Active Publication Date: 2005-07-20
QINHUANGDAO SHANHAIGUAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are quite a lot of reports on the TCM clinical syndrome differentiation treatment of this disease, with certain therapeutic effects, and some reports, but most of them are clinical observations or experience summaries, without comparison and statistical processing, and without basic experimental data, lack of systematic observation of symptoms, lack of Standardized diagnostic indicators, affecting the objective evaluation of clinical efficacy
On the other hand, there are few patented medicines for specific symptomatic treatment.

Method used

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  • Chinese medicine composition for treating menstrual period syndrome

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0067] Effects on content and metabolism of monoamine neurotransmitters in hypothalamus, liver and stomach tissue of adult female rat model of stagnation of liver qi

[0068] Monoamine neurotransmitters in the body are the main material basis of emotional and behavioral activities, and are closely related to pain, digestion and other functions. PMS is a "syndrome characterized by abnormal mental emotions, physical functions and behaviors that occurs before menstruation in women", and liver qi depression is one of its main syndrome types. Our previous studies have confirmed that the abnormal content and metabolism of monoamine neurotransmitters are the basic pathophysiological basis of the disease. Therefore, a rat model of stagnation of liver-qi syndrome reflecting the pathological changes of PMS was selected, Xiaoyao Pill was used as a positive control drug, and the content of the transmitter was detected by high-pressure liquid chromatography (HPLC) to carry out this experim...

experiment example 2

[0110] Effects on Blood Sex Hormone and Regulatory Hormone Levels of Adult Female Rat Model with Liver-Qi Stagnation Syndrome

[0111] Previous studies have shown that PMS may be related to fluctuations in estrogen and progesterone, which may be caused by excessive estrogen levels in the body, imbalance of estrogen and progesterone, or autonomic dysfunction. The relationship between PMS and abnormal levels of sex hormones E2, P and their regulatory hormone PRL has been affirmed by most scholars. Our study found that the normal secretion peaks of E2 and P in the blood of PMS patients with stagnation of liver qi were missing. In order to confirm the effect of the composition of the present invention on hormone levels in the blood, a rat model of stagnation of liver qi was selected for testing.

[0112] Materials and Methods

[0113] 1 Animals Wistar healthy adult rats, female, weighing 210±10g, provided by Shandong Experimental Animal Center.

[0114] 2 Drugs Same as Experime...

experiment example 3

[0133] Analgesic test

[0134] Distending pain in the head, breast and lower abdomen is a common symptom of the main syndrome of this product. In order to confirm the therapeutic effect of this product on distending pain with the effect of regulating qi and reducing swelling, this experiment was carried out by using the mouse writhing test method.

[0135] Materials and Methods

[0136] 1. Animal: Rat mouse, female, weighing 22±2g. Source, ibid.

[0137] 2. Except for glacial acetic acid (Jinan Chemical Reagent Factory), the others are the same as above. Produced, batch number: 971006.

[0138] 3. Method: animal grouping and dosage, see the table below, intragastric administration, 7 days in a row, 1h after administration on the 7th day, the experimental animals were intraperitoneally injected with 0.6% glacial acetic acid solution 0.2ml / only, and the observation records were obtained by The time from the injection to the start of writhing (latency period) and the number o...

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Abstract

The present invention relatesto a Chinese medicine composition for curing premenstrual syndrome. Said Chinese medicine copmosition is formed from tonifying medicine, medicine for relieving exterior syndrome, medicine for regulating qi, medicine for clearing away heat, medicine for dissipating damp with aromatics and medicine for promoting blood circulation and removing stasis.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating premenstrual syndrome (PMS). Background technique [0002] Premenstrual syndrome (PMS) refers to abnormal changes in mental emotion, physical function and behavior in women before menstruation. The main clinical manifestations are mental restlessness, irritability, or depression and weeping, breast tenderness, headache, decreased ability to work and manage the house, and behaviors that tend to lose control 3 to 14 days before menstruation. PMS is a common and frequently-occurring disease in gynecology. Although it is usually not life-threatening, it has a monthly periodicity and seriously affects the quality of life of patients. Therefore, it has attracted the attention of the medical community in recent years. [0003] The cause of premenstrual stress is not very clear yet. Modern medical research believes that premenstrual stress may be related to fluctuations in estrog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P15/00
Inventor 张珍玉乔明琦张惠云谢凤瑛
Owner QINHUANGDAO SHANHAIGUAN PHARMA CO LTD
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