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Bobtail bacterin of neuraminidase for preventing influenza virus and preparing method

A technology for neuraminidase and influenza prevention, which is applied in the field of truncated neuraminidase vaccine and its preparation, can solve the problems that influenza virus is easy to mutate, cannot overcome the cross-protection ability of DNA vaccine, and achieve good immune protection effect

Inactive Publication Date: 2005-08-31
WUHAN INST OF VIROLOGY CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, influenza virus is prone to mutations, and it still cannot overcome the problem of poor cross-protection ability of DNA vaccines

Method used

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  • Bobtail bacterin of neuraminidase for preventing influenza virus and preparing method
  • Bobtail bacterin of neuraminidase for preventing influenza virus and preparing method

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Embodiment Construction

[0021] The present invention will be further described below in conjunction with example and accompanying drawing.

[0022] This vaccine is a truncated NA vaccine for preventing influenza virus, and its component is the truncated A / PR / 8 / 34 influenza virus NA gene. The complete nucleotide sequence of the NA gene of A / PR / 8 / 34 influenza virus. The coding region of the gene is 1365 nucleotides in length and encodes a protein product with a size of 454 amino acids. In this gene, nt58~nt1365 or nt1~nt1299 Fragment is the shortest guard sequence.

[0023] The vaccine includes: (1) a truncated neuraminidase nucleic acid vaccine for preventing influenza virus, that is, a truncated NA DNA vaccine for preventing influenza virus. (2) A truncated neuraminidase protein vaccine for preventing influenza virus.

[0024] 1. Truncated NA DNA vaccine against influenza virus

[0025] It is prepared by replacing the full-length A / PR / 8 / 34 influenza virus NA gene with the truncated A / PR / 8 / 34 influ...

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Abstract

A truncated neuraminidase vaccine for preventing influenza features that its active component is a truncated A / PR / 8 / 34 influenza virus VA gene instead of a full-length one and the shortest potector sequence nt 58-nt1365 or nt 1-nt 1299 in its full nucleoside sequent is determined, so finding an effective approach to prepare said vaccine. Its preparing process is also disclosed.

Description

technical field [0001] The invention belongs to a biological product, in particular to a truncated neuraminidase vaccine for preventing influenza virus and a preparation method thereof. Background technique [0002] Influenza virus is one of the main causes of human death. It can cause acute respiratory infection and seriously endanger human health and life. Neuraminidase (NA) is a major glycoprotein anchored on the surface of the lipid bilayer membrane of influenza virus, and exists in the form of tetramers on the viral membrane. NA is one of the main antigens of influenza virus, which can induce the corresponding antibody production. Although the antibodies induced by NA have no neutralizing effect and cannot prevent the virus from entering the body, they can interfere with the release of progeny viruses and the spread of the virus. [0003] At present, the only effective way for humans to prevent influenza is to adopt active immunization, that is, to inoculate inactiva...

Claims

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Application Information

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IPC IPC(8): A61K39/00A61K48/00A61P31/16C12N15/14C12N15/52
Inventor 陈则
Owner WUHAN INST OF VIROLOGY CHINESE ACADEMY OF SCI
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