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Chinese medicine capsules for treating coronary heart disease and hyperlipidemia and production thereof

A technology of soft capsule preparation and hyperlipidemia, applied in soft capsule preparation and its preparation, Chinese medicine soft capsule preparation and preparation field for treating coronary heart disease and hyperlipidemia, which can solve the problems of unfavorable patients taking, perishable, single To solve problems such as large dosage at one time, to achieve the effects of improving stability, storage and transportation capacity, improving stability, and facilitating absorption

Inactive Publication Date: 2005-10-12
刘现永
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But it has following shortcoming as a kind of Chinese medicine oral liquid: (1) because royal jelly in the side perishes easily in aqueous solution, oral liquid is unfavorable for the storage of preparation
(2) The oral liquid is made of water extract of traditional Chinese medicine, which has the bad smell of traditional Chinese medicine, which is not good for patients to take
(3) Because it is an oral liquid, the single dose is large, and it is inconvenient to transport and carry

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Crush 400g of astragalus, 15g of ginseng, and 20g of Polygonatum odoratum into coarse powder, add water to soak for 2 hours, decoct three times, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate at 0.1Pa at 70°C until the relative density is 1.20, add ethanol to make the alcohol content reach 70%, stir well, stand at 4°C for 36 hours, filter, recover the ethanol from the filtrate and concentrate to a relative density of 1.20, dry under reduced pressure at 70°C, and pulverize into fine powder, spare. Get 50g of royal jelly freeze-dried powder, mix it with the above-mentioned fine powder, and add the drug fine powder and the matrix in a ratio of 1: 1.2 by weight into the matrix made of polyethylene glycol 400 and polyethylene glycol 6000, Mix well, and grind into a uniform suspension through colloid milling to obtain the contents of the soft capsule; gelatin, glycerin, water and polyethylene glycol 400 (weight ratio: 1:0.3:1:0.05) are made...

Embodiment 2

[0034] Crush 200g of Astragalus membranaceus, 7.5g of ginseng, and 10g of Polygonatum odoratum into coarse powder, soak in water for 0.5 hours, decoct three times, 1 hour each time, combine the decoctions, filter, and concentrate the filtrate to relative density at 0.1Pa, 50°C 1.10, add ethanol to make the alcohol content reach 60%, stir well, let it stand at 1°C for 24 hours, filter, recover the ethanol from the filtrate and concentrate to a relative density of 1.10, dry under reduced pressure at 60°C, and pulverize into fine powder ,spare. Take 25g of royal jelly freeze-dried powder, mix it with the above-mentioned fine powder, add the drug fine powder to the matrix at a ratio of 1:0.6 by weight, add it to the matrix made of soybean oil and beeswax, mix it, and grind it through colloid milling into a uniform suspension to obtain the contents of the soft capsule; gelatin, glycerin, water and polysorbate (weight ratio 1:0.25:0.8:0.05) are made into a capsule material, and the ...

Embodiment 3

[0036] Grind astragalus 1000g, ginseng 37.5g, Polygonatum 50g into coarse powder, soak in water for 3 hours, decoct twice for 3 hours each time, combine the decoctions, filter, and concentrate the filtrate at 0.1Pa, 80°C to relative The density is 1.30, add ethanol to make the alcohol content reach 75%, fully stir, stand at 4°C for 48 hours, filter, recover the ethanol from the filtrate and concentrate to a relative density of 1.30, dry under reduced pressure at 90°C, and crush into fine Powder, spare. Get 125g of royal jelly freeze-dried powder, mix it with the above-mentioned fine powder, and add the drug fine powder and the matrix at a ratio of 1:2.5 by weight, add it to the matrix made of salad oil and lecithin, mix well, and pass through the colloid mill. Grind into a uniform suspension to obtain the contents of the soft capsule; make gelatin, glycerin, water and polysorbate (weight ratio 1:0.35:1.2:0.05) into a capsule material, and compress the contents into a soft caps...

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PUM

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Abstract

A Chinese medicine in the form of softgel for treating coronary heart disease and hyperlipemia is prepared from astragalus root, ginseng, fragrant solomouseal rhizome and freeze-dried royal jelly powder. Its preparing process is also disclosed.

Description

Technical field: [0001] The invention relates to a soft capsule preparation and a preparation method thereof, in particular to a traditional Chinese medicine soft capsule preparation for treating coronary heart disease and hyperlipidemia and a preparation method thereof, belonging to the field of traditional Chinese medicine preparations. Background technique: [0002] With the continuous improvement of social productivity and production technology, people's lives are also becoming more and more prosperous, but at the same time, the side effects brought by high-protein and high-fat diets cannot be underestimated. Among them: cardiovascular and cerebrovascular diseases are a major threat to human health. killer. Among the medicines for treating cardiovascular and cerebrovascular diseases, traditional Chinese medicines have the advantages of definite curative effect and less toxic and side effects when taken for a long time, and are very popular among patients. At present, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/644A61P3/06A61P9/10
Inventor 刘现永
Owner 刘现永