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Use of panaxadiol group saponin in preparing anti-shock medicine

A technology of ginseng diol and saponin, which is applied in the direction of drug combination, medical formula, medical preparations containing active ingredients, etc., can solve the problems of large side effects, achieve the effect of small side effects, significant curative effect, and overcome side effects

Inactive Publication Date: 2005-10-19
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Overcome the shortcomings of current Western medicine such as dexamethasone with large side effects in anti-shock

Method used

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  • Use of panaxadiol group saponin in preparing anti-shock medicine
  • Use of panaxadiol group saponin in preparing anti-shock medicine
  • Use of panaxadiol group saponin in preparing anti-shock medicine

Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0023] Experimental example: The effect of panaxadiol saponins (PDS) on experimental cardiogenic shock in mongrel dogs

[0024] 1 Experimental materials

[0025] 1.1 Drugs Ginsengdiol Saponins PDS Anti-shock Injection, hereinafter referred to as PDS: Provided by the Department of Natural Medicine Chemistry, Jilin University, light yellow powder, purity above 85%, prepared with 5% glucose solution to the required concentration before the experiment. SM injection: produced by the Pharmaceutical Factory of West China University of Medical Sciences, production batch number: 2000401. Sodium pentobarbital: Shanghai Chemical Reagent Sub-packaging Plant, batch number: 990612. Nitrotetrazolium chloride: produced by Shanghai Qianjin Chemical Reagent Factory, batch number: 20000502. Lidocaine hydrochloride injection: produced by Shanghai Fosun Zhaohui Pharmaceutical Co., Ltd., batch number: 020913.

[0026] The biochemical kits LDH, AST, CPK, SOD, MDA, NO, NOS, LD are all produced by Nanjing...

Embodiment 1

[0121] Capsules: 100g of ginsengdiol group saponins, 150g of starch, mix well, and put them into size 0 capsules to make 1000 capsules, specification: 0.1g / capsule. Adults take orally, 1 capsule / time, twice daily.

Embodiment 2

[0123] Oral liquid: 1.5g ginsenoside saponins, add 700ml of water, heat to dissolve, let cool, filter, add 200g of sucrose to the filtrate, then add water to 1000ml, sub-package, specification: 10ml / piece. Adults take orally, 20ml / time, three times a day.

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PUM

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Abstract

The relates to the application of panaxadiol saponin in preparing anti-shock medicine, and belongs to the field of new use of effective Chinese medicine components. The present invention aims at applying panaxadiol saponin in preparing medicine for resisting cardiac shock. The present invention has the features of less side effect and high curative effect, and is superior to available anti-shock Western medicines, such as dexamethasone.

Description

Technical field [0001] The invention belongs to a new medical application field of effective ingredients of traditional Chinese medicine. Background technique [0002] Shock is referred to as "surgery" in the "Guidelines for the Pharmacology of New Chinese Medicines". This category of syndromes includes "hemorrhagic shock", "septic shock", "cardiogenic shock", "anaphylactic shock", "Traumatic shock" and so on. Shock is a common syndrome or pathological process secondary to a variety of diseases, and is a clinical crisis. [0003] "Dushen Decoction" has a long history of being used in the treatment of "Jietuo". Ginsenosides are saponins extracted from traditional Chinese medicine ginseng. Solvent extraction and column chromatography were used to separate Panaxadiol Saponins (PDS) and Panaxatriol Saponins (PTS). PDS is a dammarane-type tetracyclic triterpene saponins, mainly composed of ginsenosides Rb1, Rb2, Rb3, Rc, Rd, etc. Its molecular structure combines 3 to 4 molecules of su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K31/7048A61P9/02
Inventor 赵雪俭陈燕萍李扬赵丹刘洁刘喜春计国义马兴元
Owner JILIN UNIV
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