Method for preparing axcnic high pure oxymatrine

An oxymatrine, high-purity technology, applied in the directions of organic chemistry, bulk chemical production, etc., can solve the problems of complex process steps, low yield, high energy consumption, and achieve high extraction efficiency, large extraction concentration gradient, and high efficiency. The effect of dissipating phase change heat

Inactive Publication Date: 2005-10-26
黑龙江麦迪欣澳逸医药技术咨询有限公司
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Problems solved by technology

[0005] In order to solve the disadvantages of complex and cumbersome process steps, high energy consumption and low yield in the existing method, the present invention provides a method for preparing sterile high-purity oxymatrine

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  • Method for preparing axcnic high pure oxymatrine

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specific Embodiment approach 1

[0012] Specific embodiment 1: This embodiment prepares aseptic high-purity oxymatrine in this way: a. Select high-quality dried matrine as raw material, crush the raw material decoction pieces into coarse powder, pass through a 80-100 mesh sieve, and grind the coarse Put the powder into the intelligent continuous countercurrent extraction equipment of traditional Chinese medicine, add alkali solution to extract for 8-10 hours, and the amount of alkali solution is 50-60% of the material weight; 2 medium, under the conditions of pressure 20-30MPa and temperature 30-40°C, extract for 10-15min, extract twice and then spray dry to obtain extraction powder; c. Put the extraction powder into the reaction kettle and use appropriate Dissolve the powder in EtOH, add the catalyst, seal the reaction vessel, and feed in N 2 To evacuate the air, and then introduce H at a pressure of 2 to 5 atmospheres 2 React for 2 to 3 hours, the reaction is over, and then centrifuged (the separated catal...

specific Embodiment approach 2

[0013] Specific embodiment two: this embodiment prepares oxymatrine according to the technical process in Fig. 1, and the specific technical process is as follows: a, select 500Kg of Sophora japonica produced in Northeast China, grind it into coarse powder, pass through an 80-mesh sieve, and pack the coarse powder into traditional Chinese medicine Intelligent continuous countercurrent extraction equipment, add sodium hydroxide solution with a weight concentration of 5% (the amount is 60% of the material weight) to extract for 8 to 10 hours; b, add the extract to the supercritical extraction kettle, and feed CO 2 Medium, the pressure is controlled at 20-30MPa, the temperature is controlled at 30-40°C, and the time is 10-15min. Continuously extract twice, and then spray dry to obtain the extracted powder; c. Put the extracted powder into the reaction kettle, and use an appropriate amount of Dissolved EtOH, added Ni as a catalyst (the weight ratio of the catalyst to the extraction...

specific Embodiment approach 3

[0014] Specific embodiment three: This embodiment prepares oxymatrine according to the process flow shown in Figure 1. The specific process is as follows: a. Select 500Kg of Sophora flavescens produced in Northeast China, grind it into coarse powder, pass through a 100-mesh sieve, and pack the coarse powder into the traditional Chinese medicine intelligence Continuous countercurrent extraction equipment, adding an alkali solution with a weight concentration of 8% (the amount of alkali solution is 50% of the weight of the material) to extract for 8 to 10 hours; b. Add the extract to the supercritical extraction kettle, and feed CO 2 Medium, the pressure is controlled at 20-30MPa, the temperature is controlled at 30-40°C, and the time is 10-15min. Continuously extract twice, and then spray dry to obtain the extracted powder; c. Put the extracted powder into the reaction kettle, and use an appropriate amount of Dissolved EtOH, added Ni as a catalyst (the weight ratio of the cataly...

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Abstract

The present invention relates to a method for preparing sterile high-purity oxymatrine. Said method uses dried flavescent sophora root as raw material and adopts the following main procedures: pulverizing, continuous counter-current extraction, alkaline solution extraction, supercritical Co2 extraction, centrifugal separation, concentrating and drying, pH regulation and reduced pressure distillation, etc. to prepare the invented product. Said invention also provides the concrete steps of the above-mentioned every procedure and whole preparation process.

Description

Technical field: [0001] The invention improves the preparation process of oxymatrine, and relates to a preparation process of sterile high-purity oxymatrine extracted and separated from leguminous plants such as Sophora flavescens, Sophora flavescens, Bean root and the like. Background technique: [0002] Sophora flavescens is one of the traditional medicines with a long history in my country. Motherland medicine believes that matrine is cold in nature and bitter in taste, and has the functions of clearing heat and dampness, reducing jaundice, diuresis, and detoxification. Oxymatrine (Oxymatrine) is a white solid with the molecular formula C 15 h 24 o 2 , the structural formula is: [0003] It is an alkaloid extracted and separated from plants such as leguminous plants Sophora flavescens, Sophora flavescens, and mountain bean root. It can be used for the preparation of therapeutic drugs for diseases such as hepatitis B and gynecology. In addition, it has played a posi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D455/00
CPCY02P20/54
Inventor 王连政李翼
Owner 黑龙江麦迪欣澳逸医药技术咨询有限公司
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