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Adsorbents for oral administration, remedies or preventives for kidney diseases and remedies or preventives for liver diseases

A technology for kidney disease and liver disease, applied in the direction of urinary system diseases, anti-drugs, digestive system, etc., can solve problems such as heavy economic burden, and achieve the effect of small adsorption and improved selective adsorption characteristics

Inactive Publication Date: 2005-11-02
KUREHA KAGAKU KOGYO KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since this type of hemodialysis type artificial kidney uses a special device, professional technicians are required for safety management, and there are also disadvantages such as heavy physical, mental, and economical burdens on the patient due to taking blood out of the body. , it is not entirely satisfactory

Method used

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  • Adsorbents for oral administration, remedies or preventives for kidney diseases and remedies or preventives for liver diseases
  • Adsorbents for oral administration, remedies or preventives for kidney diseases and remedies or preventives for liver diseases
  • Adsorbents for oral administration, remedies or preventives for kidney diseases and remedies or preventives for liver diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Spherical phenolic resin (particle size = 10 to 700 μm: trade name “High Performance True Spherical Resin Marlin HF500 Type”; manufactured by Qunyei Chemical Co., Ltd.) was sieved with a 250 μm sieve to remove fine powder, and the removed Put 150 g of micropowdered spherical phenol resin into a vertical reaction tube made of quartz with an orifice plate, raise the temperature to 350°C for 1.5 hours under nitrogen flow, and then raise the temperature to 900°C for 6 hours, then keep it at 900°C for 1 hours, 68.1 g of spherical carbonaceous materials were obtained. Subsequently, activation treatment was performed at 900° C. under a mixed gas atmosphere of nitrogen (3 NL / min) and water vapor (2.5 NL / min). When the packing density of spherical activated carbon was reduced to 0.5mL / g, the activation treatment was terminated to obtain 29.9 g of spherical activated carbon (yield 19.9 wt%).

[0085] The characteristics of the obtained spherical activated carbon are shown in Tab...

Embodiment 2

[0087] Instead of the phenolic resin used in Example 1 ( Qun Rong Chemical Co., Ltd.), all the other repeat the method described in Example 1 to obtain spherical activated carbon. The yield was 26.5%.

[0088] The characteristics of the obtained spherical activated carbon are shown in Table 1 and Table 2.

Embodiment 3

[0090] The spherical activated carbon obtained in Example 1 is subjected to an oxidation treatment at 470° C. for 3 hours and 15 minutes through a fluidized bed under a mixed gas atmosphere of nitrogen and oxygen with an oxygen concentration of 18.5 vol%, and then again in a fluidized bed under a nitrogen atmosphere. At 900°C for 17 minutes, reduction treatment was performed to obtain surface-modified spherical activated carbon.

[0091] The characteristics of the obtained surface-modified spherical activated carbon are shown in Table 1 and Table 2.

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PUM

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Abstract

An adsorbent for oral administration, characterized by comprising a spherical activated carbon prepared from a thermosetting resin as a carbon source, wherein a diameter is 0.01 to 1 mm, and a specific surface area determined by Langmuir's adsorption equation is 1000 m<2> / g or more; and an adsorbent for oral administration, characterized by comprising a surface-modified spherical activated carbon prepared from a thermosetting resin as a carbon source, wherein a diameter is 0.01 to 1 mm, a specific surface area determined by Langmuir's adsorption equation is 1000 m<2> / g or more, a total amount of acidic groups is 0.40 to 1.00 meq / g, and a total amount of basic groups is 0.40 to 1.10 meq / g. The adsorbents for oral administration exhibit a useful selective adsorbability, that is, a less adsorbability of useful substances in a body, and a greater adsorbability of toxic substances.

Description

technical field [0001] The present invention is composed of an oral adsorbent made of spherical activated carbon with a special pore structure, and a surface-modified spherical activated carbon made by further oxidizing and reducing the aforementioned spherical activated carbon and having the same special pore structure. related to oral sorbents. In addition, the present invention relates to a therapeutic or preventive agent for kidney disease and a therapeutic or preventive agent for liver disease, which contain the aforementioned adsorbent for oral administration as an active ingredient. [0002] According to the adsorbent for oral administration of the present invention, it not only has a small adsorption capacity for beneficial components in the human body such as digestive enzymes, but also has a selective adsorption property of high adsorption capacity for toxic toxins. The aforementioned selective adsorption properties of the existing oral adsorbents are significantly ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/44A61P1/16A61P13/12A61P39/02
CPCA61K33/44A61P1/16A61P13/12A61P39/02A61K9/14
Inventor 园部直弘森本进吉原秀行花塚浩之荒川信
Owner KUREHA KAGAKU KOGYO KK
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