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Process for preparing beta-tricalcium phosphate by octacalcium phosphate as precursor

A technology of octacalcium phosphate and tricalcium phosphate, which is applied in the fields of biomedical materials, bone tissue engineering and human bone repair, can solve the problems of unsuitability for large-scale production and difficulty in solid-liquid separation, saving time and solving filtration difficulties. , The effect of easy liquid-solid separation

Inactive Publication Date: 2005-11-23
SICHUAN UNIV
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  • Summary
  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

[0005] In the current wet process for preparing β-TCP, soluble calcium salts [such as Ca(NO 3 ) 2 ] and phosphate [such as (NH 4 ) 2 HPO 4 ] reaction and acid-base neutralization reaction [Ca(OH) 2 and H 3 PO 4 ] are two traditional methods, but they all have common disadvantages: even if the precipitate produced is aged for a long time (> 24h), solid-liquid separation is difficult, and it is not suitable for large-scale production

Method used

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Examples

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example 1

[0013] 35% by weight of anhydrous calcium chloride and 65% by weight of anhydrous sodium carbonate are used as raw materials. They are dissolved in deionized water to form a saturated solution, mixed under vigorous stirring, and stirred until blue-white flocculent precipitate appears. It is filtered, washed with water, washed with absolute ethanol, and dried to produce high-purity calcium carbonate. The high-purity calcium carbonate is mixed into a slurry, and phosphoric acid is prepared as a solution according to 1:5. The ingredients are mixed according to the Ca / P ratio (molar ratio) of 1.50 and mixed under stirring; after the addition is completed, ultrasonically shake for 30 minutes, and then continue to stir the reaction After 3 hours, the precursor was prepared after filtering, washing with water, washing with absolute ethanol, and drying. The precursor was calcined at 950°C for 2 hours to prepare β-tricalcium phosphate powder.

example 2

[0015] Anhydrous calcium chloride 40% (weight percent) and anhydrous sodium carbonate 60% (weight percent) are used as raw materials. They are dissolved in deionized water to form a saturated solution, mixed under vigorous stirring, and stirred until blue-white flocculent precipitate appears. It is filtered, washed with water, washed with absolute ethanol, and dried to produce high-purity calcium carbonate. The high-purity calcium carbonate is mixed into a slurry, and phosphoric acid is prepared as a solution according to 1:5. The ingredients are mixed according to the Ca / P ratio (molar ratio) of 1.50 and mixed under stirring; after the addition is completed, ultrasonically shake for 45 minutes, and then continue to stir the reaction After 2.5 hours, the precursor was prepared after filtering, washing with water, washing with absolute ethanol, and drying. The precursor was calcined at 1000°C for 2 hours to prepare β-tricalcium phosphate powder.

[0016]

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PUM

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Abstract

The invention discloses a process for preparing beta-tricalcium phosphate by octacalcium phosphate as precursor which comprises the following steps, (1) preparing high purity calcium carbonate powder, (2) preparing octacalcium phosphate precursor, (3) preparing beta-tricalcium phosphate. By employing Ca8H2(PO4)2 5H2O as precursor in the preparing procedure for the substitution of calcium deficiency hydroxyapatite (HA), solid-liquid separation can be realized easily.

Description

Technical field [0001] The invention belongs to the technical fields of biomedical materials, bone tissue engineering and human bone repair, and relates to a new process for preparing β-tricalcium phosphate using calcium chloride, sodium carbonate and phosphoric acid as raw materials and octacalcium phosphate as a precursor. Background technique [0002] Calcium phosphate ceramics are a large class of biological materials in bioactive ceramics. Currently, hydroxyapatite (HA) and tricalcium phosphate (TCP) are more commonly used. Among them, β-tricalcium phosphate (β-TCP) combines well with bone without rejection reaction. Compared with HA, β-TCP is easier to dissolve in the body, and its solubility is about 10-20 times higher than that of HA, which is the formation of new bone Provides richer Ca, P and other beneficial elements than HA; after β-TCP is degraded, new bone tissue is gradually replaced. Generally speaking, β-TCP has good osteoconductivity, biocompatibility and biodeg...

Claims

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Application Information

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IPC IPC(8): C01B25/32
Inventor 尹光福周大利张云姚亚东杨为中王月华
Owner SICHUAN UNIV
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