CpG-N ODN gene sequence with high immunological activity CpG-S ODN and antagonism CpG-N ODN and use thereof
Patent Information
- Authority / Receiving Office
- CN · China
- Current Assignee / Owner
- ARMY MEDICAL UNIV
- Publication Date
- 2005-11-23
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The present invention relates to an oligonucleotide and its application in medicine, in particular, to an immune stimulating oligonucleotide (CpG-S ODN) and an oligonucleotide (CpG-S ODN) with an antagonistic effect on it. -N ODN). Background technique
[0002] Oligonucleotide fragments containing unmethylated CpG are the smallest unit of bacterial DNA, so oligonucleotides containing unmethylated CpG that have an immunostimulatory effect are called immunostimulatory oligonucleotides (Immnostimulatory oligonucleotides, CpG-S ODN). Its structural feature is a hexamer containing a CpG motif, that is, a complementary palindromic structure of 6 bases. The hexamer must contain at least one CpG dinucleotide, and there must be a purine at the 5' end of CpG. The structure is similar to ApA , GpA or GpT, etc., there must be two pyrimidines such as TpT at the 3' end, and hexamers known to have immunostimulatory effects include AACGTT, AGCGCT, etc.
[0003] CpG...