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Reversibly hot gelified water soluble medicine composition

A technology of thermal gelation and composition, applied in drug delivery, pharmaceutical formulations, etc., can solve problems such as safety needs to be further verified, the influence of salt has not been studied, and gelation has not been studied.

Inactive Publication Date: 2005-12-14
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, gelation around body temperature in mammals has not been studied, nor has the effect of specific salts that are applicable
Moreover, the methoxyl content of the methyl cellulose used in this document is relatively high, exceeding the range of 27-32% methoxyl content stipulated in the Chinese Pharmacopoeia, and its safety needs to be further verified.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Dissolve 0.1g of erythromycin, 3.8g of sodium citrate, and 0.5g of chlorobutanol in 50ml of sterilized distilled water, add 4.5g of MC100 dissolved in 25ml of sterilized distilled water, and stir thoroughly with citric acid or Adjust the pH to 7.0 with sodium hydroxide, make up to 100ml with sterilized distilled water, stir and dissolve thoroughly while water cooling to obtain eye drops.

Embodiment 2

[0035] Dissolve 0.3g of levofloxacin hydrochloride, 3.5g of sodium citrate, and 0.01g of benzalkonium chloride in 50ml of sterilized distilled water, add 3.5g of MC15 dissolved in 25ml of sterilized distilled water, stir thoroughly with citric acid or Adjust the pH to 7.0 with sodium hydroxide, make up to 100ml with sterilized distilled water, stir and dissolve thoroughly while water cooling to obtain eye drops.

Embodiment 3

[0037] Dissolve 6.0 g of sodium triphosphate in 50 ml of sterilized distilled water, and adjust the pH to 5.0 with citric acid. Add 0.3 g of norfloxacin and 0.005 g of benzyl ammonium chloride to it, and then add 3.5 g of MC4000 dissolved in 25 ml of sterilized distilled water. Adjust the pH to 5.5 with citric acid, make up to 100ml with sterilized distilled water, stir and dissolve thoroughly while cooling with water to obtain eye drops.

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PUM

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Abstract

The reversibly hot gelified water soluble medicine composition may be used in pharmacological treatment and diagnosis of diseases of eyes, nasal cavity, other body cavity and skin. The composition consists of medicine in effective amount, methyl cellulose in certain concentration, salt, pH regulator, etc, and has the features of being well flowable liquid before being applied and fast gelification by the local body temperature after being applied.

Description

Technical field: [0001] The invention relates to a reversible thermogelling water-based pharmaceutical composition containing a medicinal ingredient and taking a combination of methyl cellulose and polyvalent acid salt as a matrix. It is characterized in that the aqueous pharmaceutical composition is a flowable liquid at or below room temperature, and when it is used on the parts to be treated of the human body and other mammals, it can achieve coagulation in a relatively short period of time due to the temperature rising to body temperature or close to body temperature. Gelling, which has the characteristics of prolonging the residence time of the medicinal ingredients at the medication site, increasing the biological availability of the medicinal ingredients, and prolonging the duration of the medicinal effects. Background technique: [0002] According to the investigation and retrieval of relevant information, it is found that the change of sol-gel is based on three diffe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00
Inventor 凌沛学张建强张玲董爱梅祝美华张新房
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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