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Production of bee-glue microcapsule with submicron

A technology of micro-bees and micro-capsules, applied in micro-capsules, capsule delivery, medical preparations containing active ingredients, etc., can solve the problems of water-adhesion and low absorption rate of propolis tincture

Inactive Publication Date: 2005-12-28
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mainly to solve the problems of propolis tincture's water cohesiveness and low absorption rate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] 2% ethanol solution of propolis (containing polyethylene glycol 400 is 1 / 50 of the mass percentage of propolis) is added to 1.5% solution of cyclodextrin and its derivatives, the ratio of propolis and cyclodextrin is 1:5 After 45 minutes of ultrasonic vibration, use a 0.8 μm filter membrane for suction filtration, filter the filtrate with a 0.1 μm microporous filter membrane, vacuum freeze-dry the filter residue to obtain submicron propolis microcapsules, and vacuum freeze-dry the filtrate to obtain nano-propolis.

Embodiment 2

[0010] Add 5% propolis ethanol solution (containing polyethylene glycol 400 as 1 / 5 of the mass percentage of propolis) to 3% solution of cyclodextrin and its derivatives, the ratio of propolis and cyclodextrin is 1:3 After 15 minutes of ultrasonic vibration, use a 0.8 μm filter membrane for suction filtration, filter the filtrate with a 0.1 μm microporous filter membrane, vacuum freeze-dry the filter residue to obtain submicron propolis microcapsules, and vacuum freeze-dry the filtrate to obtain nano-propolis.

Embodiment 3

[0012] Add 7% propolis ethanol solution (containing polyethylene glycol 400 as 1 / 10 of propolis mass percent) to 2% cyclodextrin and its derivatives solution, the ratio of propolis and cyclodextrin is 1:2.5 After 30 minutes of ultrasonic vibration, use a 0.8 μm filter membrane for suction filtration, filter the filtrate with a 0.1 μm microporous filter membrane, vacuum freeze-dry the filter residue to obtain submicron propolis microcapsules, and vacuum freeze-dry the filtrate to obtain nano-propolis.

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Abstract

A process for preparing the submicron softgels of propolis includes such steps as adding the alcohol solution of propolis to the solution of cyclodextrin and its derivative, ultrasonic vibrating, filtering by membrane filter, filtering by milipore membrane, vacuum freeze drying of the dregs to obtain said submicron softgels, and vacuum freeze drying of the filtrate to obtain submicron propolis particles.

Description

technical field [0001] The invention belongs to the field of propolis deep processing, and in particular relates to a method for making propolis into submicron microcapsules. Background technique [0002] Propolis is a mixture of gums, resins and tree trunk exudates collected by bees from new shoots of plants. Due to the complex composition, it is not easy to use synthesis, thermal decomposition and other methods to produce sub-micron or nano-particles like previous pharmaceuticals and chemical products. It is an opaque solid that starts to soften at 30°C, has viscosity and plasticity, and has strong hygroscopicity. Soluble in ethanol, ether, methanol, acetone, etc., insoluble in water. What needs to be solved at present is the water solubility and particle diameter control of propolis. If the particles are too small, they will be eliminated before they are absorbed in time, and they will not have the proper effect. If the particles are too large, the utilization rate is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L21/20A61K9/50A61K35/644
Inventor 胡福良李英华朱威
Owner ZHEJIANG UNIV
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