Method for extracting chimonin

A technology of mangiferin and extract, applied in the field of mangiferin extraction, can solve problems such as resource waste, and achieve the effects of simplifying the production process, avoiding the loss of active ingredients and shortening the production cycle

Active Publication Date: 2006-02-15
GUILIN NATURAL INGREDIENTS CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In my country, tens of millions of tons of mango leaves and almond leaves are burned by fruit farmers as firewood every year, resulting in a great waste of resources

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1) pre-treatment: pulverizing almond leaves;

[0026] 2) Extraction: Mix the raw materials and deionized water in a ratio of 1:3 and put them into the extraction tank, heat to boil and keep the temperature for 2 hours, collect the first extraction material liquid, and add 3 times the amount of deionized water for the second extraction water, heat to boil and keep warm for 2 hours, and collect the second extraction material liquid.

[0027] 3) Concentration under reduced pressure: the extract is introduced into a concentrator for concentration under reduced pressure, the temperature is controlled below 60° C., and the degree of vacuum is controlled above 0.06 MPa.

[0028] 4) Centrifugation: the concentrated extract is centrifuged by a centrifuge.

[0029] 5) The concentrated and centrifuged extract directly enters the macroporous resin column;

[0030] 6) Wash the column with water until the effluent is clear;

[0031] 7) Wash the column with ethanol until the efflue...

Embodiment 2

[0036] 1) Pre-treatment: crush the mango leaves after sorting and removing impurities.

[0037] 2) Extraction: put qualified raw materials into a clean extraction tank, add 10 times the amount of 65% (v / v) ethanol, and extract for the first time under reflux for 2 hours, count the time from the boiling of the solvent, control the temperature at 80°C, and keep it warm until the time is up. Squeeze out the liquid medicine, then add 8 times the amount of 65% (v / v) ethanol for reflux extraction for 3 hours for the second time, and combine the filtrates;

[0038] 3) Recovery of ethanol: pump the extracted medicinal solution into a concentration tank for concentration under reduced pressure and recovery of ethanol, the temperature is controlled below 60°C, and the vacuum degree is controlled above 0.06Mpa. After recovering until there is no alcohol smell, the medicine is hydraulically injected into the liquid storage tank;

[0039] 4) Add water, let it stand, and cool it down: the ...

Embodiment 3

[0047] 1) Pre-treatment: crushing the dried mango after sorting and removing impurities.

[0048] 2) Extraction: Mix qualified raw materials with ethanol with a weight concentration of 70% in a ratio of 1:8, and perform ultrasonic extraction. The extraction conditions are working frequency 60kHz, time 120min, and extraction 2 times;

[0049] 3) Recovery of ethanol: pump the extracted medicinal solution into a concentration tank for concentration under reduced pressure and recovery of ethanol, the temperature is controlled below 60°C, and the vacuum degree is controlled above 0.06Mpa. After recovering until there is no alcohol smell, the medicine is hydraulically injected into the liquid storage tank;

[0050] 4) Add water, let it stand, and cool it down: the ratio of the medicinal solution to the raw material for recovering ethanol should be controlled at about 1:4, if it is not enough, add water, let it stand still, and cool it down;

[0051] 5) Centrifugation: Centrifuge th...

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PUM

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Abstract

The invention discloses a method to extract chimonin by using mango leaves, almond leave or other plants contained chimonin as material, extracting with menstruum of water or low-carbon alcohols, condensing, separating to purify with pole chromatography, crystallizing and drying; wherein, the extract method comprises heating extract, ultrasonic extract, or microwave extract. The product had chimonin content more than 60% measured by HPLC method. This invention also avoids the loss to active composition, simplifies process, and cuts production cycle.

Description

technical field [0001] The invention relates to a preparation method of extracting mangiferin from mango leaves or almond leaves. Background technique [0002] Both mangoes and almonds are fruit trees that grow in the tropics and subtropics, and are widely distributed in Hainan, Guangxi, Guangdong and other provinces in my country; Guangxi Zhuang Autonomous Region is one of the main producing areas of mangoes, and it is also a key fruit tree in Guangxi. In my country, tens of millions of tons of mango leaves and almond leaves are burned by fruit growers as firewood every year, resulting in a great waste of resources. [0003] The composition of mango leaves and almond leaves is very similar. Mangiferin is a four-hydroxypyrrolidone carbon glycoside extracted from the leaves of mango trees or almond leaves of Anacardiaceae. Pharmacological studies have shown that its main function is to relieve cough and eliminate phlegm. It is the main ingredient of the Chinese patent medici...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H1/08C07H17/04
Inventor 宋云飞季永贤孙步祥梁远盛汤凌志李杰
Owner GUILIN NATURAL INGREDIENTS CORP
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