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Orally quick disintegrating lornoxicam composition and its prepn process

A technology of oral rapid disintegration and lornoxicam, which is applied in the directions of drug combination, pharmaceutical formulation, drug delivery, etc., can solve problems such as inconvenience, and achieve the effect of good taste

Active Publication Date: 2006-03-01
ZHEJIANG ZHENYUAN PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in some special cases, such as the elderly and children who have difficulty swallowing or in the absence of water, it becomes inconvenient to take the regular dosage form of lornoxicam

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Formulation for Tablet 1

[0078] Preparation Content of ingredients in each tablet

[0079] (mg)

[0080] Lornoxicam 4

[0081] Glyceryl behenate (Compritol ATO 888) 2

[0082] Mannitol 60

[0083] Microcrystalline Cellulose (pH102) 60

[0084] Cross-linked polyvinylpyrrolidone 10

[0085] Aspartame 10

[0086] mint flavor 4

[0087] Acesulfame Potassium 2

[0088] Micronized silica gel 5

[0089] Preparation method: Sieve Lornoxicam (Zhejiang Zhenyuan Pharmaceutical Co., Ltd.) and Compritol (Gattefossé, France) separately with an 80-mesh sieve, and then mix them uniformly. Heat the mixture in a constant temperature oven at 85°C-90°C for 10-15 minutes, so that Lornoxicam and Compritol are blended under continuous stirring. The molten mixture was then cooled to room temperature (4-25° C.), followed by crushing and sieving. Add microcrystalline cellulose (Shanghai Yunhong Chemical Co., Ltd.), croscarmellose sodium ...

Embodiment 2

[0092] Recipe for Tablet 2

[0093] Preparation Content of ingredients in each tablet

[0094] (mg)

[0095] Lornoxicam 8

[0096] Glyceryl Palmitostearate (Precirol®ato 5) 4

[0097] Mannitol 80

[0098] Microcrystalline Cellulose (pH102) 20

[0099] Cross-linked polyvinylpyrrolidone 10

[0100] Aspartame 10

[0101] mint flavor 4

[0102] Acesulfame Potassium 2

[0103] Micronized silica gel 3

[0104] The orally disintegrating composition was prepared by the same method as that described in Example 1, except that the lornoxicam and Precirol were continuously stirred and blended at 65-70° C., and the components and contents in the composition were as above. The hardness of the finally obtained tablet is controlled at 1.5~3kg / cm 2 , with a diameter of 8.5mm.

[0105]

Embodiment 3

[0107] Preparation Content of ingredients in each tablet

[0108] (mg)

[0109] Lornoxicam 4

[0110] Glyceryl behenate (Compritol ATO 888) 2

[0111] Croscarmellose Sodium 10

[0112]Bulking agent (mannitol) 84

[0113] The orally disintegrating composition was prepared by the same method as described in Example 1, except that the components and contents in the composition were as above. The hardness of the final obtained tablet is controlled at 0.5-1kg / cm 2 , with a diameter of 4mm.

[0114]

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PUM

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Abstract

The present invention relates to orally quick disintegrating lornoxicam composition and its preparation process. The orally quick disintegrating lornoxicam composition includes lornoxicam in 100 weight portions, pharmaceutically acceptable lipoid taste mask 25-100 weight portions, and pharmaceutically acceptable disintegrating agent 50-500 weight portions. The present invention also provides the preparation process of the oral disintegrating lornoxicam composition. The composition of the present invention can disintegrate inside oral cavity in good taste and act in stomach. The composition of the present invention is easy taken, especially for those people with dysphagia.

Description

technical field [0001] The invention relates to an oral rapidly disintegrating composition and a preparation method thereof, in particular to an oral rapidly disintegrating composition containing lornoxicam and a preparation method thereof. Background technique [0002] Lornoxicam is a non-steroidal anti-inflammatory analgesic drug with strong analgesic and anti-inflammatory effects. It is used for acute moderate postoperative pain and pain associated with acute lumbar sciatica. The current oral dosage form of lornoxicam is a film-coated tablet, which is swallowed with water each time. However, in some special cases, such as the elderly and children who have difficulty swallowing or in the absence of water, it becomes inconvenient to take the regular dosage form of lornoxicam. [0003] Therefore, there is a need for a new formulation of lornoxicam which can be administered without water or with only a small amount of water. Contents of the invention [0004] The purpose ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/542A61K9/00A61P29/00
Inventor 张建军樊伟明俞建生
Owner ZHEJIANG ZHENYUAN PHARMA CO LTD
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