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Compound paracetamol and amantadine hydrochloride dripping pills and preparation method

A technology of compound acetaminophen dripping pills and dropping pills, which is applied in the fields of pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2006-03-08
陈茜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tablets and capsules take a long time to disintegrate; granules use a large amount of sucrose and are inconvenient to take.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Calculated by making 1000 drop pills:

[0020] Take acetaminophen, amantadine hydrochloride, chlorpheniramine maleate, artificial bezoar, and caffeine, grind them separately and sieve. Acetaminophen fine powder 12.5g, amantadine hydrochloride fine powder 5g, chlorpheniramine maleate fine powder 0.1g, artificial bezoar fine powder 0.5g, caffeine fine powder 0.75g mixed with 42g polyethylene glycol 6000 , heated to about 80°C to melt, stirred evenly, dripped with simethicone oil as the coolant, separated the dropping pills, absorbed the coolant, dried, and obtained. Each pill weighs about 60mg, and each pill contains 12.5mg of paracetamol, 5mg of amantadine hydrochloride, 0.1mg of chlorpheniramine maleate, 0.5mg of artificial bezoar, and 0.75mg of caffeine.

[0021] time

(moon)

Content (g / 20 capsules)

Amantadine Hydrochloride

Acetaminophen

0

0.104

0.241

1

0.102

0.245

2...

Embodiment 2

[0029] Calculated by making 1000 drop pills:

[0030] Take acetaminophen, amantadine hydrochloride, chlorpheniramine maleate, artificial bezoar, and caffeine, grind them separately and sieve. Paracetamol fine powder 12.5g, amantadine hydrochloride fine powder 5g, chlorpheniramine maleate fine powder 0.1g, artificial bezoar fine powder 0.5g, caffeine fine powder 0.75g and 30g polyethylene glycol 6000 and Mix 2 g of poloxamer, heat to about 80°C to melt, stir evenly, drip with simethicone oil as coolant, separate drop pills, absorb coolant, and dry to obtain. Each pill weighs about 50mg, and each pill contains 12.5mg of paracetamol, 5mg of amantadine hydrochloride, 0.1mg of chlorpheniramine maleate, 0.5mg of artificial bezoar, and 0.75mg of caffeine.

Embodiment 3

[0032] Calculated by making 1000 drop pills:

[0033] Take acetaminophen, amantadine hydrochloride, chlorpheniramine maleate, artificial bezoar, and caffeine, grind them separately and sieve. Acetaminophen fine powder 12.5g, amantadine hydrochloride fine powder 5g, chlorpheniramine maleate fine powder 0.1g, artificial bezoar fine powder 0.5g, caffeine fine powder 0.75g, and 36g polyethylene glycol 6000 and 1g of stearic acid, heated to about 80°C to melt, stirred evenly, dripped with simethicone as the coolant, separated the dropping pills, sucked off the coolant, and dried to obtain the product. Each pill weighs about 55mg, and each pill contains 12.5mg of paracetamol, 5mg of amantadine hydrochloride, 0.1mg of chlorpheniramine maleate, 0.5mg of artificial bezoar, and 0.75mg of caffeine.

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PUM

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Abstract

The present invention discloses a compound paracetamol amantadine hydrochloride dripping pills preparation and its preparation method. Said compound preparation is made up by using paracetamol, amantadine hydrochloride, chlorphenamine maleate, artificial cow-bezoar, caffeine and matrix for making dripping pills.

Description

technical field [0001] The invention belongs to the field of pharmaceutical technology, in particular to a compound acetaminophen dripping pill prepared from paracetamol, amantadine hydrochloride, chlorpheniramine maleate, artificial bezoar, caffeine and a dropping pill base . Background technique [0002] Flu is a common respiratory disease caused by a variety of viruses, which can take place throughout the year. The incidence of colds does not distinguish between age, gender, occupation, and region. Many people suffer from colds every year. It is a disease that almost everyone has experienced personally. "Headache and brain fever" visits from time to time, which can make people uncomfortable and affect work and study. Seriously, it will cause complications and cause greater health hazards. The main symptoms of a cold are sneezing, nasal congestion, runny nose, sore throat, cough, headache, and fatigue. At present, there is no special effective method for treating colds,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61K31/522A61K9/20A61P31/00A61P11/00
Inventor 陈茜滕慧丽
Owner 陈茜
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