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Male fertility assay method and device

An active and motility technology used in the field of analysis of male fertility, which can solve the problems of inability to distinguish sperm cells from other cell types, high cost of fertility management, and inability to analyze sperm cell motility characteristics.

Inactive Publication Date: 2006-03-08
ADVANCED FLUIDIX LAB
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  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

The high cost of fertility management is due in part to the need for trained professionals and laboratory testing
Low-cost private alternatives to semen analysis, such as the home cytometer available in the UK, cannot distinguish sperm cells from other cell types in a semen sample and cannot analyze any motility of sperm cells in the sample

Method used

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  • Male fertility assay method and device
  • Male fertility assay method and device
  • Male fertility assay method and device

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Embodiment Construction

[0033] A. Definition

[0034] In this specification, unless otherwise specified, the following terms have the following meanings.

[0035] "Microchannel"refers to a channel having width and depth dimensions that facilitate the movement of sperm through the channel in a manner similar to that in vivo through the fallopian tubes. To count individual cells on their way, the channel is narrowed to restrict the sperm to a single file. Typically, microchannels have width and depth dimensions of about 10 to 100 microns. Microchannels can have any cross-sectional shape, such as circular or rectangular, and be up to several centimeters in length.

[0036] "Labeling compound"refers to any compound that binds to or incorporates on or within a sperm cell such that the sperm cell contains a detectable marker, preferably a fluorescent marker.

[0037] "Motility" refers to the ability to move, and "sperm motility" refers specifically to the property of sperm cells that can move through ...

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Abstract

A method and device for assaying sperm motility in a forward direction and density of active sperm in a semen sample are disclosed. The device includes a microfluidics structure having a sample reservoir, a downstream collection region and a microchannel extending therebetween. The microchannel is dimensioned to confine sample sperm to single-direction movement within the channel, such that sperm in a semen sample placed in the sample reservoir enter and migrate along the microchannel toward and into the collection region. Also included is a detector for detecting the presence of labeled sperm in the microchannel or collection region, and an electronics unit operatively connected to the detector for (i) receiving detector signals, (ii) based on the detector signals received, determining sperm motility and density in the sperm sample, and (iii) displaying information related to sperm motility and density.

Description

field of invention [0001] The present invention relates to methods and devices for analyzing male fertility, in particular methods and devices for determining positive sperm motility and active sperm density. Background of the invention [0002] In the United States and other industrialized countries, couples have a 15-20% chance of infertility without medical intervention. Male infertility directly accounts for about one-third and is a dominant factor in more than half of all pregnancy failures. In order to design the most appropriate medical intervention, the condition of a man's semen sample must be accurately determined. According to the World Health Organization (WHO) standards for male fertility, the main factors controlling male fertility are semen volume, sperm cell density, motility, positive progression, and morphology. These standards are not independent. For example, a semen sample with a high density of positively advancing spermatozoa also has high motility ...

Claims

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Application Information

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IPC IPC(8): G01N15/14B01L3/00G01P13/00
CPCG01N15/1484G01N15/1459G01N2015/1075G01N1/31C12N5/0612G01N2015/1486G01N2015/1027
Inventor A·M·阿拉瓦尼斯J·L·派尔
Owner ADVANCED FLUIDIX LAB
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