Scanning type up-converting phosphor particle distribution state detector

Abstract

The invention relates to a scanning type upper rectification phosphorescence distributed tester, which comprises: a light-electricity changing and signal processing system, a data collecting and controlling system, a phosphorescence exciting light path and a phosphorescence receiving light path, wherein the phosphorescence exciting light path comprises an infrared semiconductor laser and a spherical adjusting mirror, a dichroic mirror and a focus / collimation lens and a scanning plane on the direction of the exciting light beam from the infrared semiconductor laser, wherein the scanning plane is used to lay the paper which is on the focus plane of the focus / collimation lens; the phosphorescence receiving light path is formed by the focus / collimation lens, the dichroic mirror, and a light filter, a rear focus mirror, an one-focus narrow slit baffle and the light-electricity changer; the one-focus narrow slit baffle is positioned on the rear focus plane of the rear focus mirror.

Description

technical field [0001] The invention relates to immunochromatography technology, in particular to a scanning type up-transfer phosphorescent particle distribution state detector. The detector can scan, detect and interpret the results of immunochromatographic test paper based on up-transfer phosphorescence technology, so as to realize the detection of pathogens, antigens, antibodies, illegal drugs, markers of major diseases (tumor, cancer and diabetes, etc.) Rapid, multiplexed, quantitative detection of substances. Background technique [0002] At present, in immunochromatography technology, enzymes, colloidal gold, and colored rubber beads are usually used as markers, and test strips are used as detection carriers. Visual methods, CCD and CMOS image sensors are usually used to detect the detection strips of test strips. The concentration of the target analyte in the sample can be determined by comparing the luminescence intensity of the marker on the quality control strip....

AI Technical Summary

Problems solved by technology

[0004] 1. Low detection sensitivity

Generally, light-emitting diodes are used as the illumination source, and the illumination intensity is low; when receiving images with an area array CCD or CMOS image sensor, a large area of ​​illumination is required, so it is difficult to obtain high-intensity illumination on the surface of the tested paper strip; moreover, the area array CCD or CMOS image sensor Sensitivity of the sensor is usually low

If visual observation is used, in addition to low sensitivity, the detection results are also affected by human factors

[0005] 2. Low reliability of test results

Since the luminous intensity of the marker on the surface of the tested test strip is directly proportional to the intensity of the illumination light, in order to obtain stable detection results, these techniques require large-area uniform illumination, which is usually difficult to achieve

[0006] 3. Due to the limitation of detection sensitivity, generally only qualitative analysis can be carried out, and accurate quantitative detection cannot be realized;

Thereby, the test strip made of this marker cannot be preserved for a long time, so it cannot be checked again;

[0008] 5. There is no bactericidal function, when the test result is positive, it may cause harm to the test personnel

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