Compounding injection prepn. contg. extractives of red-rooted salvia and total notogisennoside and its prepn. method

A technology for total saponins of Panax notoginseng and injection preparations, applied in the field of compound injections and preparation thereof, to achieve the effects of preventing acute attacks, preventing the recurrence of cerebrovascular diseases, and having a wide range of safe doses

Inactive Publication Date: 2006-06-14
秦引林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The compound preparation of salvia miltiorrhiza extract and Panax notoginseng saponins alone has not been seen so far, and there is no report in the relevant literature. Both have definite curative effects on acute cardiovascular and cerebrovascular diseases. After compounding, they can exert synergistic effects, especially for cardiovascular In the acute stage of cerebrovascular attack, it can take effect quickly and achieve the therapeutic purpose

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1: the preparation of injection

[0044] Take 200g of Danshen extract, add 1000ml of water for injection to dissolve completely. Take 200g of Panax notoginseng saponins and add 2-4L of water for injection to dissolve. Slowly add the aqueous solution of Danshen extract into the aqueous solution of Panax notoginseng saponins, stir until clear while adding, and dilute to 10L with water for injection. The medicinal liquid is ultrafiltered through an ultrafiltration membrane with a pore size of 10,000 molecular weight, potted, 10 ml / bottle, and sterilized to obtain an injection.

Embodiment 2

[0045] Embodiment 2: the preparation of transfusion

[0046] Take 200g of Danshen extract, grind it finely, add 2400ml of water for injection and stir to dissolve completely. Take 200g of Panax notoginseng saponins and add 2-4L of water for injection to dissolve. Slowly add the aqueous solution of the salvia miltiorrhiza extract to the aqueous solution of the total saponins of Panax notoginseng, stir while adding, and add an osmotic pressure regulator to an isotonic amount, and the isotonic agent is at least one of mannitol, sodium chloride or glucose , and diluted with water for injection to 100L or 250L, and stirred evenly. The medicinal solution is ultrafiltered by an ultrafiltration membrane with a pore size of 30,000 molecular weight, supplemented with an appropriate amount of water for injection, subpackaged into 100ml or 250ml / bottle, filled with caps, and sterilized to obtain an infusion solution.

Embodiment 3

[0047] Embodiment 3: the preparation of freeze-dried powder injection

[0048] Take 200g of Salvia miltiorrhiza extract, grind finely, add 40ml of water for injection to dissolve, set aside. Take 200 g of Panax notoginseng total saponins raw material, add appropriate amount of water for injection to dissolve. Slowly add the salvia miltiorrhiza extract solution into the aqueous solution of Panax notoginseng saponins, stir until clear while adding, dilute to 50L with water for injection, and dissolve. The medicinal solution is ultrafiltered by an ultrafiltration membrane with a flux of 10,000 molecular weight, divided into 5 ml bottles, freeze-dried, capped, and labeled to obtain powder injections, with a total of 10,000 bottles.

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PUM

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Abstract

A Chinese medicine in the form of injection for treating cerebral infarction, cerebral ischemia, coronary heart disease, angina pectoris, myocardiac infarction, etc is prepared from the extract of red sage root (50-80%) and arasaponin (20-50%).

Description

technical field [0001] The invention relates to a compound injection composed of traditional Chinese medicine salvia miltiorrhiza extract and Panax notoginseng saponins in a certain proportion and a preparation method thereof. It belongs to the field of medical technology. Background technique [0002] Cardiovascular and cerebrovascular diseases are the number one killer that endangers human life and health. According to the latest statistics, 17 million people died of cardiovascular diseases in the world in 2000, accounting for 1 / 3 of the total number of deaths from various causes in the world. It is estimated that by 2020 This number will increase to 25 million in 2010, 80 percent of which will be in developing countries. [0003] According to the analysis of the causes of death in my country in 1997, among the causes of death among urban population, tumors accounted for the first place, and cerebrovascular diseases accounted for the second place. Disease takes second pla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/08A61P9/10
Inventor 何龙其秦引林
Owner 秦引林
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